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Efficacy of Platelet-Rich Plasma in Retarding Intervertebral Disc Degeneration: A Meta-Analysis of Animal Studies
Joint Authors
Zhou, Qiang
Li, Pei
Zhang, Ruijie
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
Several animal studies have demonstrated the positive effects of platelet-rich plasma (PRP) on disc degeneration retardation.
The present meta-analysis was to verify the efficacy of PRP in retarding disc degeneration in animal.
Methods.
Relevant studies were identified and evaluated according to our inclusion and exclusion criteria.
The standardized mean difference (SMD) and related 95% confidence interval (95% CI) were estimated to assess PRP efficiency.
Results.
In total, eleven studies were included in this meta-analysis.
Significant differences were found in the PRP treatment group, which showed increased disc height (SMD = 2.66, 95% CI: 1.86, 3.47, p=0.000), increased MRI T2 signal intensity (SMD = −3.29, 95% CI: −4.44, −2.13, p=0.000), and decreased histological degeneration grade (SMD = −4.28, 95% CI: −5.26, −3.30, p=0.000).
However, no significant increase in collagen II expression was found (SMD = 25389.74, 95% CI: −27585.72, 78365.21, p=0.348).
Apart from the subgroup analysis of the disc height based on animal species (pig) and disc degeneration model (chymopapain induction), other subgroup analysis based on animal species (rabbit and rat), study design, disc degeneration model, and follow-up period demonstrated that PRP treatment can significantly restore disc height and increase MRI T2 signal intensity.
Conclusions.
PRP treatment is potentially effective in restoring disc height of rodent rabbit and rat, reducing histological degeneration grade, and increasing MRI T2 image signal.
PRP injection may be promising therapy for retarding disc degeneration.
American Psychological Association (APA)
Li, Pei& Zhang, Ruijie& Zhou, Qiang. 2017. Efficacy of Platelet-Rich Plasma in Retarding Intervertebral Disc Degeneration: A Meta-Analysis of Animal Studies. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138790
Modern Language Association (MLA)
Li, Pei…[et al.]. Efficacy of Platelet-Rich Plasma in Retarding Intervertebral Disc Degeneration: A Meta-Analysis of Animal Studies. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138790
American Medical Association (AMA)
Li, Pei& Zhang, Ruijie& Zhou, Qiang. Efficacy of Platelet-Rich Plasma in Retarding Intervertebral Disc Degeneration: A Meta-Analysis of Animal Studies. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138790