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Recombinant Immunotoxin Therapy of Glioblastoma: Smart Design, Key Findings, and Specific Challenges
Joint Authors
Wang, Paul C.
Gu, Xinbin
Zhu, Shaowei
Liu, Yuanyi
Shan, Liang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-29
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Recombinant immunotoxins (RITs) refer to a group of recombinant protein-based therapeutics, which consists of two components: an antibody variable fragment or a specific ligand that allows RITs to bind specifically to target cells and an engineered toxin fragment that kills the target cells upon internalization.
To date, over 1,000 RITs have been generated and significant success has been achieved in the therapy of hematological malignancies.
However, the immunogenicity and off-target toxicities of RITs remain as significant barriers for their application to solid tumor therapy.
A group of RITs have also been generated for the treatment of glioblastoma multiforme, and some have demonstrated evidence of tumor response and an acceptable profile of toxicity and safety in early clinical trials.
Different from other solid tumors, how to efficiently deliver the RITs to intracranial tumors is more critical and needs to be solved urgently.
In this article, we first review the design and expression of RITs, then summarize the key findings in the preclinical and clinical development of RIT therapy of glioblastoma multiforme, and lastly discuss the specific issues that still remain to forward RIT therapy to clinical practice.
American Psychological Association (APA)
Zhu, Shaowei& Liu, Yuanyi& Wang, Paul C.& Gu, Xinbin& Shan, Liang. 2017. Recombinant Immunotoxin Therapy of Glioblastoma: Smart Design, Key Findings, and Specific Challenges. BioMed Research International،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1138801
Modern Language Association (MLA)
Zhu, Shaowei…[et al.]. Recombinant Immunotoxin Therapy of Glioblastoma: Smart Design, Key Findings, and Specific Challenges. BioMed Research International No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1138801
American Medical Association (AMA)
Zhu, Shaowei& Liu, Yuanyi& Wang, Paul C.& Gu, Xinbin& Shan, Liang. Recombinant Immunotoxin Therapy of Glioblastoma: Smart Design, Key Findings, and Specific Challenges. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1138801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138801