Nicotine Enhances Interspecies Relationship between Streptococcus mutans and Candida albicans

Joint Authors

Liu, Shiyu
Li, Mingyun
Qiu, Wei
Zhang, Keke
Ren, Biao
Cheng, Lei
Zhou, Xuedong
He, Jinzhi
Xu, Xin

Source

BioMed Research International

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-02-09

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Streptococcus mutans and Candida albicans are common microorganisms in the human oral cavity.

The synergistic relationship between these two species has been deeply explored in many studies.

In the present study, the effect of alkaloid nicotine on the interspecies between S.

mutans and C.

albicans is explored.

We developed a dual-species biofilm model and studied biofilm biomass, biofilm structure, synthesis of extracellular polysaccharides (EPS), and expression of glucosyltransferases (Gtfs).

Biofilm formation and bacterial and fungal cell numbers in dual-species biofilms increased in the presence of nicotine.

More C.

albicans cells were present in the dual-species biofilms in the nicotine-treated groups as determined by scanning electron microscopy.

The synthesis of EPS was increased by 1 mg/ml of nicotine as detected by confocal laser scanning microscopy.

The result of qRT-PCR showed gtfs expression was upregulated when 1 mg/ml of nicotine was used.

We speculate that nicotine promoted the growth of S.

mutans, and more S.

mutans cells attracted more C.

albicans cells due to the interaction between two species.

Since S.

mutans and C.

albicans are putative pathogens for dental caries, the enhancement of the synergistic relationship by nicotine may contribute to caries development in smokers.

American Psychological Association (APA)

Liu, Shiyu& Qiu, Wei& Zhang, Keke& Zhou, Xuedong& Ren, Biao& He, Jinzhi…[et al.]. 2017. Nicotine Enhances Interspecies Relationship between Streptococcus mutans and Candida albicans. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138819

Modern Language Association (MLA)

Liu, Shiyu…[et al.]. Nicotine Enhances Interspecies Relationship between Streptococcus mutans and Candida albicans. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1138819

American Medical Association (AMA)

Liu, Shiyu& Qiu, Wei& Zhang, Keke& Zhou, Xuedong& Ren, Biao& He, Jinzhi…[et al.]. Nicotine Enhances Interspecies Relationship between Streptococcus mutans and Candida albicans. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138819

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1138819