Cooccurrences of Putative Endogenous Retrovirus-Associated Diseases
Joint Authors
Staege, Martin Sebastian
Brütting, Christine
Emmer, Alexander
Kornhuber, Malte E.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
At least 8% of the human genome is composed of endogenous retrovirus (ERV) sequences.
ERVs play a role in placental morphogenesis and can sometimes protect the host against exogenous viruses.
On the other hand, ERV reactivation has been found to be associated with different diseases, for example, multiple sclerosis (MS), schizophrenia, type 1 diabetes mellitus (T1D), or amyotrophic lateral sclerosis (ALS).
Little is known about the cooccurrence of these diseases.
If all these diseases are caused by ERV, antiretroviral therapy should perhaps also show some effects in the other diseases.
Here, we summarize literature demonstrating that some ERV-associated diseases seem to appear together more often than expected, for example, MS and ALS, MS and T1D, MS and schizophrenia, or ALS and T1D.
In contrast, some ERV-associated diseases seem to appear together less frequently than expected, for example, schizophrenia and T1D.
Besides, some reports demonstrate amelioration of MS, ALS, or schizophrenia under antiretroviral therapy in human immunodeficiency virus-infected patients.
If such results could be confirmed in larger studies, alternative therapy strategies for ERV-associated diseases like MS and schizophrenia might be possible.
American Psychological Association (APA)
Brütting, Christine& Emmer, Alexander& Kornhuber, Malte E.& Staege, Martin Sebastian. 2017. Cooccurrences of Putative Endogenous Retrovirus-Associated Diseases. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1138836
Modern Language Association (MLA)
Brütting, Christine…[et al.]. Cooccurrences of Putative Endogenous Retrovirus-Associated Diseases. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1138836
American Medical Association (AMA)
Brütting, Christine& Emmer, Alexander& Kornhuber, Malte E.& Staege, Martin Sebastian. Cooccurrences of Putative Endogenous Retrovirus-Associated Diseases. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1138836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138836