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Diagnostic and Therapeutic Biomarkers in Glioblastoma: Current Status and Future Perspectives
Joint Authors
Kaspera, Wojciech
Szopa, Wojciech
Burley, Thomas A.
Kramer-Marek, Gabriela
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Glioblastoma (GBM) is a primary neuroepithelial tumor of the central nervous system, characterized by an extremely aggressive clinical phenotype.
Patients with GBM have a poor prognosis and only 3–5% of them survive for more than 5 years.
The current GBM treatment standards include maximal resection followed by radiotherapy with concomitant and adjuvant therapies.
Despite these aggressive therapeutic regimens, the majority of patients suffer recurrence due to molecular heterogeneity of GBM.
Consequently, a number of potential diagnostic, prognostic, and predictive biomarkers have been investigated.
Some of them, such as IDH mutations, 1p19q deletion, MGMT promoter methylation, and EGFRvIII amplification are frequently tested in routine clinical practice.
With the development of sequencing technology, detailed characterization of GBM molecular signatures has facilitated a more personalized therapeutic approach and contributed to the development of a new generation of anti-GBM therapies such as molecular inhibitors targeting growth factor receptors, vaccines, antibody-based drug conjugates, and more recently inhibitors blocking the immune checkpoints.
In this article, we review the exciting progress towards elucidating the potential of current and novel GBM biomarkers and discuss their implications for clinical practice.
American Psychological Association (APA)
Szopa, Wojciech& Burley, Thomas A.& Kramer-Marek, Gabriela& Kaspera, Wojciech. 2017. Diagnostic and Therapeutic Biomarkers in Glioblastoma: Current Status and Future Perspectives. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138846
Modern Language Association (MLA)
Szopa, Wojciech…[et al.]. Diagnostic and Therapeutic Biomarkers in Glioblastoma: Current Status and Future Perspectives. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1138846
American Medical Association (AMA)
Szopa, Wojciech& Burley, Thomas A.& Kramer-Marek, Gabriela& Kaspera, Wojciech. Diagnostic and Therapeutic Biomarkers in Glioblastoma: Current Status and Future Perspectives. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138846