RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis
Joint Authors
Sato, Ryo
Nakano, Teppei
Hosonaga, Mari
Sampetrean, Oltea
Harigai, Ritsuko
Sasaki, Takashi
Koya, Ikuko
Kudoh, Jun
Saya, Hideyuki
Arima, Yoshimi
Okano, Hideyuki
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Metastasis is the main cause of treatment failure and death in cancer patients.
Metastasis of tumor cells to the brain occurs frequently in individuals with breast cancer, non–small cell lung cancer, or melanoma.
Despite recent advances in our understanding of the causes and in the treatment of primary tumors, the biological and molecular mechanisms underlying the metastasis of cancer cells to the brain have remained unclear.
Metastasizing cancer cells interact with their microenvironment in the brain to establish metastases.
We have now developed mouse models of brain metastasis based on intracardiac injection of human breast cancer or melanoma cell lines, and we have performed RNA sequencing analysis to identify genes in mouse brain tissue and the human cancer cells whose expression is associated specifically with metastasis.
We found that the expressions of the mouse genes Tph2, Sspo, Ptprq, and Pole as well as those of the human genes CXCR4, PLLP, TNFSF4, VCAM1, SLC8A2, and SLC7A11 were upregulated in brain tissue harboring metastases.
Further characterization of such genes that contribute to the establishment of brain metastases may provide a basis for the development of new therapeutic strategies and consequent improvement in the prognosis of cancer patients.
American Psychological Association (APA)
Sato, Ryo& Nakano, Teppei& Hosonaga, Mari& Sampetrean, Oltea& Harigai, Ritsuko& Sasaki, Takashi…[et al.]. 2017. RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138871
Modern Language Association (MLA)
Sato, Ryo…[et al.]. RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138871
American Medical Association (AMA)
Sato, Ryo& Nakano, Teppei& Hosonaga, Mari& Sampetrean, Oltea& Harigai, Ritsuko& Sasaki, Takashi…[et al.]. RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138871