Meta-Analysis of the Relationship between NM23 Expression to Gastric Cancer Risk and Clinical Features
Joint Authors
Huang, Lingsha
Zhu, Bo
Fang, Min
Tao, Yifeng
Liu, Zhimin
Huang, Hao
Lao, Min
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The prognostic value of reduced NM23 expression for gastric cancer (GC) patients is still contradictory.
Thus, we conducted a meta-analysis to quantitatively evaluate the association of NM23 expression with GC risk and clinical features by analyzing 27 publications.
The result of our meta-analysis indicated that NM23 expression is markedly reduced in gastric cancer tissues (OR = 3.15; 95% CI = 1.97–5.03; P<0.001).
Furthermore, NM23 expression was negatively correlated with N stage, TNM stage, and histological grade.
However, NM23 expression was not correlated with T stage, lymphatic invasion, vascular invasion, and 5-year overall survival rate.
In conclusion, reduced NM23 expression correlated with gastric cancer risk, but its association with GC clinical features remains inconclusive.
Therefore, large-scale and well-designed studies, which use uniform antibody and criterion of NM23 positive expression, are required to further validate the role of the NM23 in predicting GC progression.
American Psychological Association (APA)
Fang, Min& Tao, Yifeng& Liu, Zhimin& Huang, Hao& Lao, Min& Huang, Lingsha…[et al.]. 2017. Meta-Analysis of the Relationship between NM23 Expression to Gastric Cancer Risk and Clinical Features. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138881
Modern Language Association (MLA)
Fang, Min…[et al.]. Meta-Analysis of the Relationship between NM23 Expression to Gastric Cancer Risk and Clinical Features. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1138881
American Medical Association (AMA)
Fang, Min& Tao, Yifeng& Liu, Zhimin& Huang, Hao& Lao, Min& Huang, Lingsha…[et al.]. Meta-Analysis of the Relationship between NM23 Expression to Gastric Cancer Risk and Clinical Features. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138881