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Miniature Dielectric Barrier Discharge Nonthermal Plasma Induces Apoptosis in Lung Cancer Cells and Inhibits Cell Migration
Joint Authors
Yildirim-Ayan, Eda
Karki, Surya B.
Ayan, Halim
Eisenmann, Kathryn M.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Traditional cancer treatments like radiotherapy and chemotherapy have drawbacks and are not selective for killing only cancer cells.
Nonthermal atmospheric pressure plasmas with dielectric barrier discharge (DBD) can be applied to living cells and tissues and have emerged as novel tools for localized cancer therapy.
The purpose of this study was to investigate the different effects caused by miniature DBD (mDBD) plasma to A549 lung cancer cells.
In this study, A549 lung cancer cells cultured in 12 well plates were treated with mDBD plasma for specified treatment times to assess the changes in the size of the area of cell detachment, the viability of attached or detached cells, and cell migration.
Furthermore, we investigated an innovative mDBD plasma-based therapy for localized treatment of lung cancer cells through apoptotic induction.
Our results indicate that plasma treatment for 120 sec causes apoptotic cell death in 35.8% of cells, while mDBD plasma treatment for 60 sec, 30 sec, or 15 sec causes apoptotic cell death in 20.5%, 14.1%, and 6.3% of the cell population, respectively.
Additionally, we observed reduced A549 cell migration in response to mDBD plasma treatment.
Thus, mDBD plasma system can be a viable platform for localized lung cancer therapy.
American Psychological Association (APA)
Karki, Surya B.& Yildirim-Ayan, Eda& Eisenmann, Kathryn M.& Ayan, Halim. 2017. Miniature Dielectric Barrier Discharge Nonthermal Plasma Induces Apoptosis in Lung Cancer Cells and Inhibits Cell Migration. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138886
Modern Language Association (MLA)
Karki, Surya B.…[et al.]. Miniature Dielectric Barrier Discharge Nonthermal Plasma Induces Apoptosis in Lung Cancer Cells and Inhibits Cell Migration. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1138886
American Medical Association (AMA)
Karki, Surya B.& Yildirim-Ayan, Eda& Eisenmann, Kathryn M.& Ayan, Halim. Miniature Dielectric Barrier Discharge Nonthermal Plasma Induces Apoptosis in Lung Cancer Cells and Inhibits Cell Migration. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138886