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A Comparison of Genetic Diversity of COX-III Gene in Lowland Chickens and Tibetan Chickens
Joint Authors
Zhang, Pu
Xu, Zhongxian
Li, Diyan
Ma, Tianyuan
Liu, Xueqin
Zhang, Gongying
Li, Sichen
Zhang, Long
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
To obtain a full understanding of the genetic diversity of the cytochrome oxidase III gene (COX-III) and its association with high altitude adaptation in Tibetan chickens, we sequenced COX-III in 12 chicken populations (155 Tibetan chickens and 145 other domestic chickens).
We identified a total of 11 single nucleotide polymorphisms (SNPs) and 12 haplotypes (Ha1–Ha12).
Low genetic diversity (haplotype diversity = 0.531 ± 0.087, nucleotide diversity = 0.00125) was detected for COX-III, and haplotype diversity of Tibetan chicken populations (0.750 ± 0.018) was markedly higher than lowland chicken populations (0.570 ± 0.028).
Obvious genetic differentiation (nucleotide divergence = 0.092~0.339) and conspicuous gene communication (gene flow = 0.33~32.22) among 12 populations suggested that Tianfu black-bone fowl (white feather) was possibly introduced from Tibetan chicken.
SNP m.10587 T>C affects the specific functions of the COX enzyme.
Haplotype Ha3 was found in Tibetan chickens, and SNP m.10115G>A caused an amino acid substitution (Val62Ile) associated with phospholipid binding, while mutations m.10017C>A and m.10555G>A and the previously reported SNP m.10065T>C reduced the hydropathy index to some extent.
Together, this indicates that the mitochondrial membrane is more hydrophobic in Tibetan chickens.
American Psychological Association (APA)
Liu, Xueqin& Zhang, Pu& Zhang, Gongying& Li, Sichen& Zhang, Long& Xu, Zhongxian…[et al.]. 2017. A Comparison of Genetic Diversity of COX-III Gene in Lowland Chickens and Tibetan Chickens. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138891
Modern Language Association (MLA)
Liu, Xueqin…[et al.]. A Comparison of Genetic Diversity of COX-III Gene in Lowland Chickens and Tibetan Chickens. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1138891
American Medical Association (AMA)
Liu, Xueqin& Zhang, Pu& Zhang, Gongying& Li, Sichen& Zhang, Long& Xu, Zhongxian…[et al.]. A Comparison of Genetic Diversity of COX-III Gene in Lowland Chickens and Tibetan Chickens. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138891