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Combining Carcinoembryonic Antigen and Platelet to Lymphocyte Ratio to Predict Brain Metastasis of Resected Lung Adenocarcinoma Patients
Joint Authors
Wang, Yan-Yang
Hai, Ping
Wang, Wei
Bian, Chao
Xia, Di
He, Jin-Xi
Zhao, Ren
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We aimed to evaluate the role of pretreatment carcinoembryonic antigen (CEA) and platelet to lymphocyte ratio (PLR) in predicting brain metastasis after radical surgery for lung adenocarcinoma patients.
The records of 103 patients with completely resected lung adenocarcinoma between 2013 and 2014 were reviewed.
Clinicopathologic characteristics of these patients were assessed in the Cox proportional hazards regression model.
Brain metastasis occurred in 12 patients (11.6%).
On univariate analysis, N2 stage (P = 0.013), stage III (P = 0.016), increased CEA level (P = 0.006), and higher PLR value (P = 0.020) before treatment were associated with an increased risk of developing brain metastasis.
In multivariate model analysis, CEA above 5.2 ng/mL (P = 0.014) and PLR ≥ 120 (P = 0.036) remained as the risk factors for brain metastasis.
The combination of CEA and PLR was superior to CEA or PLR alone in predicting brain metastasis according to the receiver operating characteristic (ROC) curve analysis (area under ROC curve, AUC 0.872 versus 0.784 versus 0.704).
Pretreatment CEA and PLR are independent and significant risk factors for occurrence of brain metastasis in resected lung adenocarcinoma patients.
Combining these two factors may improve the predictability of brain metastasis.
American Psychological Association (APA)
Wang, Wei& Bian, Chao& Xia, Di& He, Jin-Xi& Hai, Ping& Zhao, Ren…[et al.]. 2017. Combining Carcinoembryonic Antigen and Platelet to Lymphocyte Ratio to Predict Brain Metastasis of Resected Lung Adenocarcinoma Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1138897
Modern Language Association (MLA)
Wang, Wei…[et al.]. Combining Carcinoembryonic Antigen and Platelet to Lymphocyte Ratio to Predict Brain Metastasis of Resected Lung Adenocarcinoma Patients. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1138897
American Medical Association (AMA)
Wang, Wei& Bian, Chao& Xia, Di& He, Jin-Xi& Hai, Ping& Zhao, Ren…[et al.]. Combining Carcinoembryonic Antigen and Platelet to Lymphocyte Ratio to Predict Brain Metastasis of Resected Lung Adenocarcinoma Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1138897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138897