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Peripheral Antinociception Induced by Aripiprazole Is Mediated by the Opioid System
Joint Authors
Moreira, Fabrício de Araújo
Ferreira, Renata Cristina Mendes
Almeida-Santos, Ana Flávia
Duarte, Igor Dimitri Gama
Aguiar, Daniele C.
Romero, Thiago Roberto Lima
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Aripiprazole is an antipsychotic drug used to treat schizophrenia and related disorders.
Our previous study showed that this compound also induces antinociceptive effects.
The present study aimed to assess the participation of the opioid system in this effect.
Methods.
Male Swiss mice were submitted to paw pressure test and hyperalgesia was induced by intraplantar injection of prostaglandin E2 (PGE2, 2 μg).
Aripiprazole was injected 10 min before the measurement.
Naloxone, clocinnamox, naltrindole, nor-binaltorphimine, and bestatin were given 30 min before aripiprazole.
Nociceptive thresholds were measured in the 3rd hour after PGE2 injection.
Results.
Aripiprazole (100 μg/paw) injected locally into the right hind paw induced an antinociceptive effect that was blocked by naloxone (50 μg/paw), a nonselective opioid receptor antagonist.
The role of μ-, δ-, and κ-opioid receptors was investigated using the selective antagonists, clocinnamox (40 μg/paw), naltrindole (15, 30, and 60 μg/paw), and nor-binaltorphimine (200 μg/paw), respectively.
The data indicated that only the δ-opioid receptor antagonist inhibited the peripheral antinociception induced by aripiprazole.
Bestatin (400 μg), an aminopeptidase-N inhibitor, significantly enhanced low-dose (25 μg/paw) aripiprazole-induced peripheral antinociception.
Conclusion.
The results suggest the participation of the opioid system via δ-opioid receptor in the peripheral antinociceptive effect induced by aripiprazole.
American Psychological Association (APA)
Ferreira, Renata Cristina Mendes& Almeida-Santos, Ana Flávia& Duarte, Igor Dimitri Gama& Aguiar, Daniele C.& Moreira, Fabrício de Araújo& Romero, Thiago Roberto Lima. 2017. Peripheral Antinociception Induced by Aripiprazole Is Mediated by the Opioid System. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1138914
Modern Language Association (MLA)
Ferreira, Renata Cristina Mendes…[et al.]. Peripheral Antinociception Induced by Aripiprazole Is Mediated by the Opioid System. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1138914
American Medical Association (AMA)
Ferreira, Renata Cristina Mendes& Almeida-Santos, Ana Flávia& Duarte, Igor Dimitri Gama& Aguiar, Daniele C.& Moreira, Fabrício de Araújo& Romero, Thiago Roberto Lima. Peripheral Antinociception Induced by Aripiprazole Is Mediated by the Opioid System. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1138914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138914