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Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs
Joint Authors
Kim, Bonglee
Park, Moon Nyeo
Song, Hyo Sook
Kim, Myungsun
Lee, Min-Jung
Cho, Whisung
Lee, Hyun-Jin
Hwang, Cho-Hyun
Kim, Soojong
Hwang, Yechae
Kang, Beomku
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Common care for glioblastoma multiforme (GBM) is a surgical resection followed by radiotherapy and temozolomide- (TMZ-) based chemotherapy.
Unfortunately, these therapies remain inadequate involving severe mortality and recurrence.
Recently, new approaches discovering combinations of multiple inhibitors have been proposed along with the identification of key driver mutations that are specific to each patient.
To date, this approach is still limited by the lack of effective therapy.
Hopefully, novel compounds derived from natural products are suggested as potential solutions.
Inhibitory effects of natural products on angiogenesis and metastasis and cancer suppressive effect of altering miRNA expression are provident discoveries.
Angelica sinensis accelerates apoptosis by their key substances influencing factors of apoptosis pathways.
Brazilin displays antitumor features by making influence on reactive oxygen species (ROS) intensity.
Sargassum serratifolium, flavonoids, and so on have antimetastasis effect.
Ficus carica controls miRNA that inhibits translation of certain secretory pathway proteins during the UPR.
Serratia marcescens and patupilone (EPO 906) are physically assessed materials through clinical trials related to GBM progression.
Consequently, our review puts emphasis on the potential of natural products in GBM treatment by regulating multiple malignant cancer-related pathway solving pending problem such as reducing toxicity and side effect.
American Psychological Association (APA)
Park, Moon Nyeo& Song, Hyo Sook& Kim, Myungsun& Lee, Min-Jung& Cho, Whisung& Lee, Hyun-Jin…[et al.]. 2017. Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs. BioMed Research International،Vol. 2017, no. 2017, pp.1-24.
https://search.emarefa.net/detail/BIM-1138929
Modern Language Association (MLA)
Park, Moon Nyeo…[et al.]. Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs. BioMed Research International No. 2017 (2017), pp.1-24.
https://search.emarefa.net/detail/BIM-1138929
American Medical Association (AMA)
Park, Moon Nyeo& Song, Hyo Sook& Kim, Myungsun& Lee, Min-Jung& Cho, Whisung& Lee, Hyun-Jin…[et al.]. Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-24.
https://search.emarefa.net/detail/BIM-1138929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138929