Corneal Collagen Cross-Linking for Keratoconus: Systematic Review
Joint Authors
Kobashi, Hidenaga
Rong, Shi Song
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To evaluate the efficacy of collagen cross-linking (CXL) one year after treatment for keratoconus compared to no treatment by summarizing randomized controlled trials (RCTs) using a systematic review.
Methods.
Trials meeting the selection criteria were quality appraised, and the data were extracted by two independent authors.
The outcome parameters included maximum keratometry (Kmax), corneal thickness at the thinnest point, best spectacle-corrected visual acuity (BSCVA), uncorrected visual acuity (UCVA), spherical equivalent (SE) refraction, and cylindrical refraction one year after CXL.
We compared the changes in the above parameters with the control group.
Results.
We identified five RCTs involving 289 eyes that met the eligibility criteria for this systematic review.
The changes in BSCVA from baseline to one year exhibited a significant difference between the two groups.
There was no statistically significant difference between the two groups for changes in corneal thickness and cylindrical refraction.
We did not conduct a meta-analysis in Kmax, UCVA, and SE refraction because their I2 values were greater than 50%.
Conclusions.
According to the systematic review, CXL may be effective in halting the progression of keratoconus for one year under certain conditions, although evidence is limited due to the significant heterogeneity and paucity of RCTs.
American Psychological Association (APA)
Kobashi, Hidenaga& Rong, Shi Song. 2017. Corneal Collagen Cross-Linking for Keratoconus: Systematic Review. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138931
Modern Language Association (MLA)
Kobashi, Hidenaga& Rong, Shi Song. Corneal Collagen Cross-Linking for Keratoconus: Systematic Review. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138931
American Medical Association (AMA)
Kobashi, Hidenaga& Rong, Shi Song. Corneal Collagen Cross-Linking for Keratoconus: Systematic Review. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138931