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Tang-Luo-Ning Improves Mitochondrial Antioxidase Activity in Dorsal Root Ganglia of Diabetic Rats: A Proteomics Study
Joint Authors
Zhang, Taojing
Gao, Yanbin
Gong, Yanbin
Zhou, Hui
Xie, Peifeng
Guan, Song
Yi, Wenming
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Tang-luo-ning (TLN) is a traditional Chinese herbal recipe for treating diabetic peripheral neuropathy (DPN).
In this study, we investigated mitochondrial protein profiles in a diabetic rat model and explored the potential protective effect of TLN.
Diabetic rats were established by injection of streptozocin (STZ) and divided into model, alpha lipoic acid (ALA), and TLN groups.
Mitochondrial proteins were isolated from dorsal root ganglia and proteomic analysis was used to quantify the differentially expressed proteins.
Tang-luo-ning mitigated STZ-induced diabetic symptoms and blood glucose level, including response time to cold or hot stimulation and nerve conductive velocity.
As compared to the normal, there were 388 differentially expressed proteins in the TLN group, 445 in ALA group, and 451 in model group.
As compared to the model group, there were 275 differential proteins in TLN group and 251 in ALA group.
As compared to model group, mitochondrial complex III was significantly decreased, while glutathione peroxidase and peroxidase were increased in TLN group.
When compared with ALA group, the mitochondrial complex III was increased, and mitochondrial complex IV was decreased in TLN group.
Together, TLN should have a strong antioxidative activity, which appears to be modulated through regulation of respiratory complexes and antioxidases.
American Psychological Association (APA)
Zhang, Taojing& Gao, Yanbin& Gong, Yanbin& Zhou, Hui& Xie, Peifeng& Guan, Song…[et al.]. 2017. Tang-Luo-Ning Improves Mitochondrial Antioxidase Activity in Dorsal Root Ganglia of Diabetic Rats: A Proteomics Study. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138944
Modern Language Association (MLA)
Zhang, Taojing…[et al.]. Tang-Luo-Ning Improves Mitochondrial Antioxidase Activity in Dorsal Root Ganglia of Diabetic Rats: A Proteomics Study. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138944
American Medical Association (AMA)
Zhang, Taojing& Gao, Yanbin& Gong, Yanbin& Zhou, Hui& Xie, Peifeng& Guan, Song…[et al.]. Tang-Luo-Ning Improves Mitochondrial Antioxidase Activity in Dorsal Root Ganglia of Diabetic Rats: A Proteomics Study. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138944