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DNA Damage as a Driver for Growth Delay: Chromosome Instability Syndromes with Intrauterine Growth Retardation
Joint Authors
García-de Teresa, Benilde
Hernández-Gómez, Mariana
Frías, Sara
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-12
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
DNA is constantly exposed to endogenous and exogenous mutagenic stimuli that are capable of producing diverse lesions.
In order to protect the integrity of the genetic material, a wide array of DNA repair systems that can target each specific lesion has evolved.
Despite the availability of several repair pathways, a common general program known as the DNA damage response (DDR) is stimulated to promote lesion detection, signaling, and repair in order to maintain genetic integrity.
The genes that participate in these pathways are subject to mutation; a loss in their function would result in impaired DNA repair and genomic instability.
When the DDR is constitutionally altered, every cell of the organism, starting from development, will show DNA damage and subsequent genomic instability.
The cellular response to this is either uncontrolled proliferation and cell cycle deregulation that ensues overgrowth, or apoptosis and senescence that result in tissue hypoplasia.
These diverging growth abnormalities can clinically translate as cancer or growth retardation; both features can be found in chromosome instability syndromes (CIS).
The analysis of the clinical, cellular, and molecular phenotypes of CIS with intrauterine growth retardation allows inferring that replication alteration is their unifying feature.
American Psychological Association (APA)
García-de Teresa, Benilde& Hernández-Gómez, Mariana& Frías, Sara. 2017. DNA Damage as a Driver for Growth Delay: Chromosome Instability Syndromes with Intrauterine Growth Retardation. BioMed Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1138956
Modern Language Association (MLA)
García-de Teresa, Benilde…[et al.]. DNA Damage as a Driver for Growth Delay: Chromosome Instability Syndromes with Intrauterine Growth Retardation. BioMed Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1138956
American Medical Association (AMA)
García-de Teresa, Benilde& Hernández-Gómez, Mariana& Frías, Sara. DNA Damage as a Driver for Growth Delay: Chromosome Instability Syndromes with Intrauterine Growth Retardation. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1138956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138956