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The Protective Effect of Chrysanthemum indicum Extract against Ankylosing Spondylitis in Mouse Models
Joint Authors
Abdullah Al-Dhabi, Naif
Duraipandiyan, V.
Dong, Mei
Yu, Dongsheng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In traditional Chinese and Korean homeopathic medicine, Chrysanthemum indicum Linné (Asteraceae) is a time-honored herb, prescribed for the resolution of symptoms associated with inflammatory and hypertensive conditions as well as those affecting the lungs and its associated structures.
The goal of this work is to investigate the defensive role of Chrysanthemum indicum extract in fighting ankylosing spondylitis (AS) using mouse models, through which the manifestation and extent of the disease progression were measured with quantitative analysis of the intervertebral joints.
Markers of inflammation as well as oxidative stress were also analysed.
Western blot was used to quantify the levels of Nuclear Factor-κB (NF-κB) p65, Dickkopf-1 (DKK-1), and sclerostin (SOST).
Consequently, the findings of this experiment demonstrated that AS in mice that were given Chrysanthemum indicum extract had lower level of TNF-α, IL-1β, and IL-6 (P<0.05) and increased level of catalase (CAT), glutathione peroxidase (GSH-PX), and superoxide dismutase (SOD) (P<0.05).
The results also revealed that Chrysanthemum indicum supplemented with diet contributed to a decrease in Nuclear Factor-κB (NF-κB) p65 protein expression (P<0.05) and higher levels of DKK-1 and SOST proteins (P<0.05).
Therefore, we concluded that the beneficial role of Chrysanthemum indicum in AS is manifested through downregulating oxidative stress, inhibiting inflammatory mediators and NF-κB, and increasing DKK-1 and SOST levels.
American Psychological Association (APA)
Dong, Mei& Yu, Dongsheng& Duraipandiyan, V.& Abdullah Al-Dhabi, Naif. 2017. The Protective Effect of Chrysanthemum indicum Extract against Ankylosing Spondylitis in Mouse Models. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138967
Modern Language Association (MLA)
Dong, Mei…[et al.]. The Protective Effect of Chrysanthemum indicum Extract against Ankylosing Spondylitis in Mouse Models. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138967
American Medical Association (AMA)
Dong, Mei& Yu, Dongsheng& Duraipandiyan, V.& Abdullah Al-Dhabi, Naif. The Protective Effect of Chrysanthemum indicum Extract against Ankylosing Spondylitis in Mouse Models. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138967