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Ameliorative Effect of Cactus (Opuntia ficus indica) Extract on Lithium-Induced Nephrocardiotoxicity: A Biochemical and Histopathological Study
Joint Authors
Rjeibi, Ilhem
Zourgui, Lazhar
Saad, Anouar ben
Ncib, Sana
Zouari, Nacim
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Opuntia ficus indica (family Cactaceae) is used in the treatment of a variety of conditions including metal-induced toxicity.
The study reports the protective effects of Opuntia ficus indica (CCE) against lithium carbonate-induced toxicity in rats.
Nephrocardiotoxicity was induced in male Wistar rats by single dose of lithium carbonate (25 mg/kg b.w twice daily for 30 days).
Aqueous extract of Opuntia ficus indica was administered at the dose of 100 mg/kg of b.w by gavage for 60 days.
Obtained results revealed that administration of lithium carbonate caused a significant increase in serum creatinine, uric acid, and urea levels.
Additionally, a significant decrease in the level of renal and cardiac SOD, CAT, and GPx activities was associated with a significant increase of MDA levels in lithium carbonate group more than those of the control.
However, the treatment of experimental rats with CCE prevented these alterations and maintained the antioxidant status.
The histopathological observations supported the biochemical evidences of nephrocardioprotection.
CCE supplementation could protect against lithium carbonate-induced renal and cardiac injuries in rats, plausibly by the upregulation of antioxidant enzymes and inhibition of MDA to confer the protective effect.
American Psychological Association (APA)
Saad, Anouar ben& Rjeibi, Ilhem& Ncib, Sana& Zouari, Nacim& Zourgui, Lazhar. 2017. Ameliorative Effect of Cactus (Opuntia ficus indica) Extract on Lithium-Induced Nephrocardiotoxicity: A Biochemical and Histopathological Study. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138972
Modern Language Association (MLA)
Saad, Anouar ben…[et al.]. Ameliorative Effect of Cactus (Opuntia ficus indica) Extract on Lithium-Induced Nephrocardiotoxicity: A Biochemical and Histopathological Study. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1138972
American Medical Association (AMA)
Saad, Anouar ben& Rjeibi, Ilhem& Ncib, Sana& Zouari, Nacim& Zourgui, Lazhar. Ameliorative Effect of Cactus (Opuntia ficus indica) Extract on Lithium-Induced Nephrocardiotoxicity: A Biochemical and Histopathological Study. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138972