Chondrocyte-Specific Knockout of TSC-1 Leads to Congenital Spinal Deformity in Mice
Joint Authors
Chen, Yuhui
Yang, Cheng
Bai, Xiaochun
Li, Zhen
Cao, He
Chen, Keming
Lai, Pinglin
Yan, Bo
Huang, Bin
Tang, Jiajun
Fan, Shicai
Cai, Daozhang
Jin, Dadi
Zhou, Rongping
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Congenital spinal deformity is the most severe clinical orthopedic issue worldwide.
Among all the pathological processes of congenital spinal deformity, the imbalance of endochondral ossification is considered to be the most important developmental cause of spinal dysplasia.
We established chondrocyte-specific TSC-1 knockout (KO) mice to overactivate the energy metabolic component, mammalian target of rapamycin complex 1 (mTORC1), and measured the spinal development by general, imaging, histological, and Western-blot assessments.
In addition to skeletal dysplasia, the KO mice displayed severe congenital spinal deformity and significant intervertebral disc changes.
This study suggests that, in the process of endochondral ossification, excessive activation of mTORC1 signaling in chondrocytes induces obvious spinal deformity, and the chondrocytes may be the cell type responsible for congenital spinal deformity.
American Psychological Association (APA)
Yang, Cheng& Chen, Yuhui& Li, Zhen& Cao, He& Chen, Keming& Lai, Pinglin…[et al.]. 2017. Chondrocyte-Specific Knockout of TSC-1 Leads to Congenital Spinal Deformity in Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138974
Modern Language Association (MLA)
Yang, Cheng…[et al.]. Chondrocyte-Specific Knockout of TSC-1 Leads to Congenital Spinal Deformity in Mice. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138974
American Medical Association (AMA)
Yang, Cheng& Chen, Yuhui& Li, Zhen& Cao, He& Chen, Keming& Lai, Pinglin…[et al.]. Chondrocyte-Specific Knockout of TSC-1 Leads to Congenital Spinal Deformity in Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138974