Placental ABCA1 Expression Is Increased in Spontaneous Preterm Deliveries Compared with Iatrogenic Preterm Deliveries and Term Deliveries
Joint Authors
Cheng-Mao, Xie
Yan, Long
Li, Lin
Hua, Jin
Xiao-Ju, Wang
Jie-Wen, Zhang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Abnormal expression of ABCA1 and ABCG1 in the placenta can elicit lipid metabolism disorder and adverse pregnancy outcomes.
However, whether it is associated with preterm delivery remains unclear.
Our present study aimed to evaluate the relationship between abnormal expression of ABCA1 or ABCG1 and preterm delivery.
Methods.
Maternal blood and placental tissues from women with spontaneous deliveries (SPD), iatrogenic deliveries (IPD), and term deliveries (TD) were collected.
The lipid content and expression of ABCA1 and ABCG1 were subsequently measured.
Results.
Compared with IPD and TD groups, the HDL, TD, LDL, and TC levels were lower in the maternal blood but higher (except TC) in the cord blood of the SPD group.
The extracellular lipid content in the placentas of the SPD group was also notably lower relative to the IPD and TD groups.
Moreover, the protein and mRNA expressions of ABCA1 in the placentas of the SPD group were significantly higher compared with the IPD and TD groups; however, there was no obvious difference among the three groups in the protein and mRNA expressions of ABCG1.
Conclusions.
Abnormal expression of ABCA1 may be associated with the dysregulation of placental lipid metabolism and the occurrence or development of SPD.
American Psychological Association (APA)
Cheng-Mao, Xie& Yan, Long& Li, Lin& Hua, Jin& Xiao-Ju, Wang& Jie-Wen, Zhang. 2017. Placental ABCA1 Expression Is Increased in Spontaneous Preterm Deliveries Compared with Iatrogenic Preterm Deliveries and Term Deliveries. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138988
Modern Language Association (MLA)
Cheng-Mao, Xie…[et al.]. Placental ABCA1 Expression Is Increased in Spontaneous Preterm Deliveries Compared with Iatrogenic Preterm Deliveries and Term Deliveries. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1138988
American Medical Association (AMA)
Cheng-Mao, Xie& Yan, Long& Li, Lin& Hua, Jin& Xiao-Ju, Wang& Jie-Wen, Zhang. Placental ABCA1 Expression Is Increased in Spontaneous Preterm Deliveries Compared with Iatrogenic Preterm Deliveries and Term Deliveries. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138988