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Latent Class Analysis of Noninvasive Methods and Liver Biopsy in Chronic Hepatitis C: An Approach without a Gold Standard
Joint Authors
Perazzo, Hugo
Perez, Renata de Mello
Fernandes, Flavia F.
Andrade, Luiz E.
Dellavance, Alessandra
Terra, Carlos
Pereira, Gustavo
Pereira, João L.
Campos, Frederico
Ferraz, Maria L.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
To evaluate the applicability of the Latent Class Analysis (LCA) and accuracy of transient elastography (TE), aspartate-to-platelet-ratio-index (APRI), enhanced liver fibrosis (ELF), and liver biopsy (LB) for liver fibrosis assessment in a model without a gold standard.
Methods.
Significant fibrosis was defined as TE≥7.1 kPa, APRI≥1.5, ELF≥9.37, or LB METAVIR F≥2.
Cirrhosis was defined as TE≥12.5 kPa, APRI≥2.0, ELF≥10.31, or LB as METAVIR F=4.
Results.
117 patients with chronic hepatitis C were included.
In the LCA, for significant fibrosis the sensitivities and specificities (95% CI) were 0.92 (0.86–0.98) and 0.79 (0.72–0.86) for TE; 0.47 (0.40–0.54) and 0.99 (0.95–1.00) for APRI; 0.81 (0.74–0.88) and 0.78 (0.71–0.85) for ELF; and 0.86 (0.68–1.00) and 0.91 (0.79–1.00) for LB.
For cirrhosis, the sensitivities and specificities were 0.92 (0.76–1.00) and 0.94 (0.91–0.97) for TE; 0.57 (0.37–0.77) and 0.97 (0.93–1.00) for APRI; 0.94 (0.84–1.00) and 0.88 (0.82–0.94) for ELF; and 0.30 (0.12–0.48) and 1.00 for LB.
Conclusion.
LCA was useful to evaluate accuracy of methods for liver fibrosis staging.
Sensitivities and specificities of noninvasive methods were increased in LCA compared to the use of LB as the gold standard.
American Psychological Association (APA)
Fernandes, Flavia F.& Perazzo, Hugo& Andrade, Luiz E.& Dellavance, Alessandra& Terra, Carlos& Pereira, Gustavo…[et al.]. 2017. Latent Class Analysis of Noninvasive Methods and Liver Biopsy in Chronic Hepatitis C: An Approach without a Gold Standard. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138989
Modern Language Association (MLA)
Fernandes, Flavia F.…[et al.]. Latent Class Analysis of Noninvasive Methods and Liver Biopsy in Chronic Hepatitis C: An Approach without a Gold Standard. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1138989
American Medical Association (AMA)
Fernandes, Flavia F.& Perazzo, Hugo& Andrade, Luiz E.& Dellavance, Alessandra& Terra, Carlos& Pereira, Gustavo…[et al.]. Latent Class Analysis of Noninvasive Methods and Liver Biopsy in Chronic Hepatitis C: An Approach without a Gold Standard. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138989