Neutrophil Extracellular Traps Are Pathogenic in Ventilator-Induced Lung Injury and Partially Dependent on TLR4
Joint Authors
Chen, Jie
Li, Haosi
Pan, Pinhua
Su, Xiaoli
Liu, Shuai
Zhang, Lemeng
Wu, Dongdong
Li, Haitao
Dai, Minhui
Li, Yi
Hu, Chengping
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The pathogenesis of ventilator-induced lung injury (VILI) is associated with neutrophils.
Neutrophils release neutrophil extracellular traps (NETs), which are composed of DNA and granular proteins.
However, the role of NETs in VILI remains incompletely understood.
Normal saline and deoxyribonuclease (DNase) were used to study the role of NETs in VILI.
To further determine the role of Toll-like receptor 4 (TLR4) in NETosis, we evaluated the lung injury and NET formation in TLR4 knockout mice and wild-type mice that were mechanically ventilated.
Some measures of lung injury and the NETs markers were significantly increased in the VILI group.
DNase treatment markedly reduced NETs markers and lung injury.
After high-tidal mechanical ventilation, the NETs markers in the TLR4 KO mice were significantly lower than in the WT mice.
These data suggest that NETs are generated in VILI and pathogenic in a mouse model of VILI, and their formation is partially dependent on TLR4.
American Psychological Association (APA)
Li, Haosi& Pan, Pinhua& Su, Xiaoli& Liu, Shuai& Zhang, Lemeng& Wu, Dongdong…[et al.]. 2017. Neutrophil Extracellular Traps Are Pathogenic in Ventilator-Induced Lung Injury and Partially Dependent on TLR4. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138997
Modern Language Association (MLA)
Li, Haosi…[et al.]. Neutrophil Extracellular Traps Are Pathogenic in Ventilator-Induced Lung Injury and Partially Dependent on TLR4. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1138997
American Medical Association (AMA)
Li, Haosi& Pan, Pinhua& Su, Xiaoli& Liu, Shuai& Zhang, Lemeng& Wu, Dongdong…[et al.]. Neutrophil Extracellular Traps Are Pathogenic in Ventilator-Induced Lung Injury and Partially Dependent on TLR4. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138997