Clinical Significance of Hepatocyte Growth Factor and Transforming Growth Factor-Beta-1 Levels in Assessing Disease Activity in Inflammatory Bowel Disease
Joint Authors
Naguib, Rania
El-Shikh, Wafaa Mohamed
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Transforming growth factor-beta (TGF-β) and hepatocyte growth factor (HGF) are inflammatory cytokines which function as key regulators of immunological homeostasis and inflammatory responses.
They have been linked to inflammatory bowel diseases (IBD).
In this study, we aim to assess the levels of TGF-β and HGF and other inflammatory markers in patients with IBD and correlate them with the disease activity.
Study Design.
A cross-sectional study involving 100 patients with ulcerative colitis (UC) and 100 patients with Crohn’s disease (CD) and 50 control subjects.
TGF-β and HGF levels were measured and correlated with disease activity.
Results and Conclusion.
Serum levels of TGF-β and HGF were significantly higher in IBD patients compared with the control group.
In the UC group, the levels of HGF and TGF-β were significantly higher than in the CD group.
Levels of TGF-β and HGF correlate with the activity of IBD.
American Psychological Association (APA)
Naguib, Rania& El-Shikh, Wafaa Mohamed. 2020. Clinical Significance of Hepatocyte Growth Factor and Transforming Growth Factor-Beta-1 Levels in Assessing Disease Activity in Inflammatory Bowel Disease. Canadian Journal of Gastroenterology and Hepatology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1138999
Modern Language Association (MLA)
Naguib, Rania& El-Shikh, Wafaa Mohamed. Clinical Significance of Hepatocyte Growth Factor and Transforming Growth Factor-Beta-1 Levels in Assessing Disease Activity in Inflammatory Bowel Disease. Canadian Journal of Gastroenterology and Hepatology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1138999
American Medical Association (AMA)
Naguib, Rania& El-Shikh, Wafaa Mohamed. Clinical Significance of Hepatocyte Growth Factor and Transforming Growth Factor-Beta-1 Levels in Assessing Disease Activity in Inflammatory Bowel Disease. Canadian Journal of Gastroenterology and Hepatology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1138999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138999