Triclocarban and Triclosan Inhibit Human Aromatase via Different Mechanisms
Joint Authors
Ge, Ren-Shan
Zhao, Yu
Chen, Lanlan
Su, Ying
Li, Huitao
Li, Xiaoheng
Jin, Lixu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Human aromatase (CYP19A1) is an important enzyme, which produces estrogen from androgen for maintaining the female reproductive function and pregnancy.
Triclocarban and triclosan are antimicrobial chemicals added to personal care, household, and industrial products.
They could be endocrine disruptors and may disrupt human CYP19A1 activity.
In the present study, we investigated the effects of triclocarban and triclosan on estradiol production and human CYP19A1 activity in JEG-3 cells.
Triclocarban and triclosan reduced estradiol production in JEG-3 cells.
Triclocarban and triclosan inhibited human CYP19A1 with IC50 values of 15.81 and 6.26 μM, respectively.
Triclosan competitively inhibited CYP19A1, while triclocarban noncompetitively inhibited this enzyme.
Docking study showed that triclosan bound to the steroid-binding pocket of CYP19A1, while triclocarban was off this target, suggesting a different mechanism.
In conclusion, triclocarban and triclosan are inhibitors of human CYP19A1.
American Psychological Association (APA)
Li, Huitao& Zhao, Yu& Chen, Lanlan& Su, Ying& Li, Xiaoheng& Jin, Lixu…[et al.]. 2017. Triclocarban and Triclosan Inhibit Human Aromatase via Different Mechanisms. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139005
Modern Language Association (MLA)
Li, Huitao…[et al.]. Triclocarban and Triclosan Inhibit Human Aromatase via Different Mechanisms. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1139005
American Medical Association (AMA)
Li, Huitao& Zhao, Yu& Chen, Lanlan& Su, Ying& Li, Xiaoheng& Jin, Lixu…[et al.]. Triclocarban and Triclosan Inhibit Human Aromatase via Different Mechanisms. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139005