Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications
Joint Authors
Amnuaikit, Thanaporn
Limsuwan, Tunyaluk
Boonme, Prapaporn
Khongkow, Pasarat
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Ethosome formulations containing phenylethyl resorcinol (PR) were developed.
The formulation was produced from 0.5% w/v PR, 0.5% w/v cholesterol from lanolin, 3% w/v L-α-phosphatidylcholine from soybean, 30% v/v absolute ethanol, and water up to 100% v/v.
It was characterized by a vesicular size of 389 nm, low polydispersity index of 0.266, zeta potential of −34.19±0.44 mV, high PR entrapment efficiency of 71%, and good stability on storage at 4 and 30°C at 75% RH for 4 months.
In vitro studies using pig skin revealed that permeation coefficient of PR from ethosomes was significantly higher than that from liposomes.
In vitro retention profiles showed that PR accumulation in pig skin following application of ethosome formulations was 7.4-, 3.3-, and 1.8-fold higher than that achieved using liposomes, 20% propylene glycol solution, and 30% hydroethanolic solution, respectively.
An inhibition value of around 80% was measured for antityrosinase activity of PR in pig skin.
Consistently, ethosomes exhibited higher tyrosinase inhibition activity and melanin content reduction when compared to other formulations in B16 melanoma cells.
Ethosomes did not cause acute dermal irritation in albino rabbits.
These findings demonstrate that ethosomes are capable of delivering PR into the skin efficiently and hold promise for topical application of skin lightening products.
American Psychological Association (APA)
Limsuwan, Tunyaluk& Boonme, Prapaporn& Khongkow, Pasarat& Amnuaikit, Thanaporn. 2017. Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1139028
Modern Language Association (MLA)
Limsuwan, Tunyaluk…[et al.]. Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1139028
American Medical Association (AMA)
Limsuwan, Tunyaluk& Boonme, Prapaporn& Khongkow, Pasarat& Amnuaikit, Thanaporn. Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1139028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139028