Simvastatin Ameliorates PAK4 Inhibitor-Induced Gut and Lung Injury
Joint Authors
Pan, Shuming
Liu, Xuan
Chen, Liang
Fei, Aihua
Gao, Chengjin
Wu, Zengbin
Chen, Jiameng
Wang, Huiqi
Liu, Dan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
P21 activated kinase 4 (PAK4), a key regulator of cytoskeletal rearrangement and endothelial microparticles (EMPs), is released after lipopolysaccharide (LPS) stimulation.
In addition, it participates in LPS-induced lung injury.
In this study, forty-eight Sprague Dawley (SD) rats were divided into two groups, including PAK4 inhibitor (P) and PAK4 inhibitor + simvastatin (P + S) treatment groups.
All rats were given PAK4 inhibitor (15 mg/kg/d) orally.
Immediately after PAK4 inhibitor administration, simvastatin was injected intraperitoneally to P + S group animals at 20 mg/kg/day.
Then, treatment effects on the intestinal mucosal barrier and lung injury caused by PAK4 inhibitor and simvastatin were assessed.
The results showed that gut Zonula Occludens- (ZO-) 1, PAK4, mitogen-activated protein kinase 4 (MPAK4), and CD11c protein levels were reduced, while plasma endotoxin levels were increased after administration of PAK4 inhibitor.
Furthermore, compared with normal rats, wet-to-dry (W/D) values of lung tissues and circulating EMP levels were increased in the treatment group, while PAK4 and CD11c protein amounts were reduced.
Therefore, in this lung injury process induced by PAK4 inhibitor, the protective effects of simvastatin were reflected by intestinal mucosal barrier protection, inflammatory response regulation via CD11c+ cells, and cytoskeleton stabilization.
In summary, PAK4 is a key regulator in the pathophysiological process of acute lung injury (ALI) and can be a useful target for ALI treatment.
American Psychological Association (APA)
Pan, Shuming& Wu, Zengbin& Liu, Xuan& Chen, Jiameng& Wang, Huiqi& Liu, Dan…[et al.]. 2017. Simvastatin Ameliorates PAK4 Inhibitor-Induced Gut and Lung Injury. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139031
Modern Language Association (MLA)
Pan, Shuming…[et al.]. Simvastatin Ameliorates PAK4 Inhibitor-Induced Gut and Lung Injury. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139031
American Medical Association (AMA)
Pan, Shuming& Wu, Zengbin& Liu, Xuan& Chen, Jiameng& Wang, Huiqi& Liu, Dan…[et al.]. Simvastatin Ameliorates PAK4 Inhibitor-Induced Gut and Lung Injury. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139031