The Prevalence, Predictors, and In-Hospital Mortality of Hepatic Encephalopathy in Patients with Liver Cirrhosis Admitted at St. Dominic Hospital in Akwatia, Ghana
Joint Authors
Duah, Amoako
Agyei-Nkansah, Adwoa
Osei-Poku, Foster
Duah, Francisca
Ampofo-Boobi, Daniel
Peprah, Bright
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Hepatic encephalopathy (HE) is one of the most debilitating complications of cirrhosis leading to death.
Decrease in HE mortality and recurrence has been linked with timely identification and early treatment.
There is a need to document the burden, predictors, and treatment outcomes of HE in an adult population with liver cirrhosis in our setting as only reports from resource-endowed countries abound in the literature.
This study aimed therefore to determine the prevalence, predictors, and treatment outcomes of patients with liver cirrhosis admitted at St.
Dominic Hospital (SDH) in Akwatia, Ghana.
Materials and Methods.
A prospective study was conducted involving one hundred and sixty-seven (167) patients admitted at the medical wards in SDH with liver cirrhosis from January 1st, 2018, to March 24th, 2020.
The demographic and clinical features of the patients were collected using a standardized questionnaire.
Biochemical, haematological, and abdominal ultrasound scans were done for all patients.
Patients were then followed up until discharge or death.
Results.
There were 109 (65.3%) males out of the 167 patients with a mean age of 45.8 and 47.5 years for those with and without HE, respectively.
The prevalence of HE was 31.7% (53/167).
Out of 53 participants with HE, 75.5% (40/53) died.
There was a strong association between HE and death (p<0.001).
The major precipitating factor of HE was infection (64.2%).
Severe ascites (OR = 0.009) were clinical feature independently associated with HE, whereas high creatinine (OR = 0.987), blood urea nitrogen (BUN) (OR = 1.199), Child–Pugh score (CPS) (OR = 5.899), and low platelets (OR = 0.992) were the laboratory parameters and scores independently predictive of HE.
Conclusion.
HE was common among patients with liver cirrhosis admitted at SDH with high in-patient mortality.
The commonest precipitating factor for HE was infection(s).
Severe ascites, low platelet count, high creatinine, BUN, and CPS were independent predictors of HE.
American Psychological Association (APA)
Duah, Amoako& Agyei-Nkansah, Adwoa& Osei-Poku, Foster& Duah, Francisca& Ampofo-Boobi, Daniel& Peprah, Bright. 2020. The Prevalence, Predictors, and In-Hospital Mortality of Hepatic Encephalopathy in Patients with Liver Cirrhosis Admitted at St. Dominic Hospital in Akwatia, Ghana. Canadian Journal of Gastroenterology and Hepatology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1139046
Modern Language Association (MLA)
Duah, Amoako…[et al.]. The Prevalence, Predictors, and In-Hospital Mortality of Hepatic Encephalopathy in Patients with Liver Cirrhosis Admitted at St. Dominic Hospital in Akwatia, Ghana. Canadian Journal of Gastroenterology and Hepatology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1139046
American Medical Association (AMA)
Duah, Amoako& Agyei-Nkansah, Adwoa& Osei-Poku, Foster& Duah, Francisca& Ampofo-Boobi, Daniel& Peprah, Bright. The Prevalence, Predictors, and In-Hospital Mortality of Hepatic Encephalopathy in Patients with Liver Cirrhosis Admitted at St. Dominic Hospital in Akwatia, Ghana. Canadian Journal of Gastroenterology and Hepatology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1139046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139046