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Identification of Transcriptional Modules and Key Genes in Chickens Infected with Salmonella enterica Serovar Pullorum Using Integrated Coexpression Analyses
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Salmonella enterica Pullorum is one of the leading causes of mortality in poultry.
Understanding the molecular response in chickens in response to the infection by S.
enterica is important in revealing the mechanisms of pathogenesis and disease progress.
There have been studies on identifying genes associated with Salmonella infection by differential expression analysis, but the relationships among regulated genes have not been investigated.
In this study, we employed weighted gene coexpression network analysis (WGCNA) and differential coexpression analysis (DCEA) to identify coexpression modules by exploring microarray data derived from chicken splenic tissues in response to the S.
enterica infection.
A total of 19 modules from 13,538 genes were associated with the Jak-STAT signaling pathway, the extracellular matrix, cytoskeleton organization, the regulation of the actin cytoskeleton, G-protein coupled receptor activity, Toll-like receptor signaling pathways, and immune system processes; among them, 14 differentially coexpressed modules (DCMs) and 2,856 differentially coexpressed genes (DCGs) were identified.
The global expression of module genes between infected and uninfected chickens showed slight differences but considerable changes for global coexpression.
Furthermore, DCGs were consistently linked to the hubs of the modules.
These results will help prioritize candidate genes for future studies of Salmonella infection.
American Psychological Association (APA)
Liu, Baohong& Cai, JianPing. 2017. Identification of Transcriptional Modules and Key Genes in Chickens Infected with Salmonella enterica Serovar Pullorum Using Integrated Coexpression Analyses. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1139047
Modern Language Association (MLA)
Liu, Baohong& Cai, JianPing. Identification of Transcriptional Modules and Key Genes in Chickens Infected with Salmonella enterica Serovar Pullorum Using Integrated Coexpression Analyses. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1139047
American Medical Association (AMA)
Liu, Baohong& Cai, JianPing. Identification of Transcriptional Modules and Key Genes in Chickens Infected with Salmonella enterica Serovar Pullorum Using Integrated Coexpression Analyses. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1139047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139047