Serum miRNAs miR-23a, 206, and 499 as Potential Biomarkers for Skeletal Muscle Atrophy
Joint Authors
Wang, Fei
Wang, Jing
He, Jian
Li, Wenjiong
Li, Jinglong
Chen, Shengju
Zhang, Peng
Liu, Hongju
Chen, Xiaoping
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Muscle biopsy has long been expected to be replaced by noninvasive biomarkers with diagnostic value and prognostic applications for muscle atrophy.
Growing evidence suggests that circulating microRNAs (miRNAs) could act as biomarkers for numerous pathophysiological statuses.
In the present study, our results showed that the serum levels of six muscle-specific miRNAs (miR-1/23a/133/206/208b/499) were all elevated in unloading induced mice.
The medium levels of these six muscle-specific miRNAs were all elevated in starvation induced atrophic C2C12 myotubes.
Moreover, the serum levels of miR-23a/206/499 were induced in participants after 45 days of head-down bed rest (HDBR).
The levels of miR-23a/206/499 were positively correlated with the ratio of soleus volume loss in HDBR participants, indicating that they might represent the process of muscle loss.
In conclusion, our results demonstrated that circulating miRNAs could serve as useful biochemical and molecular indicators for muscle atrophy diagnosis and disease progression.
American Psychological Association (APA)
Wang, Fei& Wang, Jing& He, Jian& Li, Wenjiong& Li, Jinglong& Chen, Shengju…[et al.]. 2017. Serum miRNAs miR-23a, 206, and 499 as Potential Biomarkers for Skeletal Muscle Atrophy. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139052
Modern Language Association (MLA)
Wang, Fei…[et al.]. Serum miRNAs miR-23a, 206, and 499 as Potential Biomarkers for Skeletal Muscle Atrophy. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139052
American Medical Association (AMA)
Wang, Fei& Wang, Jing& He, Jian& Li, Wenjiong& Li, Jinglong& Chen, Shengju…[et al.]. Serum miRNAs miR-23a, 206, and 499 as Potential Biomarkers for Skeletal Muscle Atrophy. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139052