Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand?
Joint Authors
Mikolasevic, Ivana
Pavic, Tajana
Kanizaj, Tajana Filipec
Bender, Darija Vranesic
Domislovic, Viktor
Krznaric, Zeljko
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The link between metabolic syndrome (MetS) and sarcopenia has not been extensively studied, but it is evident that they share several common features.
Crucial mechanisms involved in sarcopenia-nonalcoholic fatty liver disease (NAFLD) interplay are based on effects of insulin resistance, chronic inflammation, oxidative stress, and crosstalk between organs by secretion of cytokines (hepatokines, adipokines, and myokines).
Currently, published studies confirm the association of sarcopenia with the degree of NAFLD defined by liver histology.
However, prospective studies that will give us information regarding the causal effect of NAFLD and sarcopenia are still needed.
Furthermore, there is a need for a patient-friendly, noninvasive, low-cost method for detection of loss of skeletal muscle mass, strength, and physical performance in the context of NAFLD.
Moreover, potential treatment strategies such as physical exercise and nutritional supplementation, that are usually a part of management of sarcopenia, should also be investigated in NAFLD patients, especially given the fact that for now, we do not have a good treatment option for NAFLD.
Therefore, future investigations should combine studies on NAFLD and sarcopenia in terms of physical activity and nutritional interventions such as vitamin D supplementation.
This review aims to report recent evidence concerning the links between sarcopenia and NAFLD and methods to assess sarcopenia.
American Psychological Association (APA)
Mikolasevic, Ivana& Pavic, Tajana& Kanizaj, Tajana Filipec& Bender, Darija Vranesic& Domislovic, Viktor& Krznaric, Zeljko. 2020. Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand?. Canadian Journal of Gastroenterology and Hepatology،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1139058
Modern Language Association (MLA)
Mikolasevic, Ivana…[et al.]. Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand?. Canadian Journal of Gastroenterology and Hepatology No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1139058
American Medical Association (AMA)
Mikolasevic, Ivana& Pavic, Tajana& Kanizaj, Tajana Filipec& Bender, Darija Vranesic& Domislovic, Viktor& Krznaric, Zeljko. Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand?. Canadian Journal of Gastroenterology and Hepatology. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1139058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139058