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Antioxidant and Antidiabetic Effects of Flavonoids: A Structure-Activity Relationship Based Study
Joint Authors
Latip, Jalifah
Ahmed, Qamar Uddin
Khatib, Alfi
Sarian, Murni Nazira
Mat So’ad, Siti Zaiton
Alhassan, Alhassan Muhammad
Murugesu, Suganya
Perumal, Vikneswari
Syed Mohamad, Sharifah Nurul Akilah
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The best described pharmacological property of flavonoids is their capacity to act as potent antioxidant that has been reported to play an important role in the alleviation of diabetes mellitus.
Flavonoids biochemical properties are structure dependent; however, they are yet to be thoroughly understood.
Hence, the main aim of this work was to investigate the antioxidant and antidiabetic properties of some structurally related flavonoids to identify key positions responsible, their correlation, and the effect of methylation and acetylation on the same properties.
Antioxidant potential was evaluated through dot blot, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ABTS+ radical scavenging, ferric reducing antioxidant power (FRAP), and xanthine oxidase inhibitory (XOI) assays.
Antidiabetic effect was investigated through α-glucosidase and dipeptidyl peptidase-4 (DPP-4) assays.
Results showed that the total number and the configuration of hydroxyl groups played an important role in regulating antioxidant and antidiabetic properties in scavenging DPPH radical, ABTS+ radical, and FRAP assays and improved both α-glucosidase and DPP-4 activities.
Presence of C-2-C-3 double bond and C-4 ketonic group are two essential structural features in the bioactivity of flavonoids especially for antidiabetic property.
Methylation and acetylation of hydroxyl groups were found to diminish the in vitro antioxidant and antidiabetic properties of the flavonoids.
American Psychological Association (APA)
Sarian, Murni Nazira& Ahmed, Qamar Uddin& Mat So’ad, Siti Zaiton& Alhassan, Alhassan Muhammad& Murugesu, Suganya& Perumal, Vikneswari…[et al.]. 2017. Antioxidant and Antidiabetic Effects of Flavonoids: A Structure-Activity Relationship Based Study. BioMed Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1139060
Modern Language Association (MLA)
Sarian, Murni Nazira…[et al.]. Antioxidant and Antidiabetic Effects of Flavonoids: A Structure-Activity Relationship Based Study. BioMed Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1139060
American Medical Association (AMA)
Sarian, Murni Nazira& Ahmed, Qamar Uddin& Mat So’ad, Siti Zaiton& Alhassan, Alhassan Muhammad& Murugesu, Suganya& Perumal, Vikneswari…[et al.]. Antioxidant and Antidiabetic Effects of Flavonoids: A Structure-Activity Relationship Based Study. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1139060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139060