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Risk of Hepatocellular Carcinoma Remains High in Patients with HBV-Related Decompensated Cirrhosis and Long-Term Antiviral Therapy
Joint Authors
Xie, Jing
Zhu, Dong-Mei
Ye, Chun-Yan
Qian, Mei-Yun
Xue, Yuan
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
This study aimed to evaluate the risk factors of HCC development in patients with hepatitis B virus (HBV)-related DC and who underwent long-term antiviral therapy.
Methods.
Data from 308 patients with HBV-related DC and long-term antiviral therapy were collected and retrospectively reviewed.
Cox regression analysis was used to analyze independent risk factors of HCC development.
Results.
Data from 129 patients with definite records were analyzed.
The median follow-up time was 5 years (range, 1 to 8 years).
At the end of the follow-up, 41 (31.8%) patients developed HCC, and the time from DC diagnosis to HCC incidence who received antiviral therapy was 4.4 years (range, 1–7 years).
The incidence of HCC was higher in males (30/78, 38.5%) than in females (11/51, 21.6%) (P = 0.04).
Patients who developed HCC were significantly older than those who did not develop HCC (P < 0.01).
The incidence of HCC in patients receiving nucleoside analogues, nucleotide analogues, and combination therapy was 34.7%, 38.1%, and 33.3%, respectively, and the difference showed no significant differences (P = 0.95).
Multivariate Cox regression analysis demonstrated that male gender and age ≥50 years are independent risk factors of HCC development (OR = 2.987 and 2.408; 95% CI (1.301–6.858) and (1.126–5.149); P = 0.01 and 0.02, respectively).
Conclusion.
The risk of HCC remains to be high in patients with HBV-related DC, especially in males aged ≥50 years.
American Psychological Association (APA)
Zhu, Dong-Mei& Xie, Jing& Ye, Chun-Yan& Qian, Mei-Yun& Xue, Yuan. 2020. Risk of Hepatocellular Carcinoma Remains High in Patients with HBV-Related Decompensated Cirrhosis and Long-Term Antiviral Therapy. Canadian Journal of Gastroenterology and Hepatology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1139063
Modern Language Association (MLA)
Zhu, Dong-Mei…[et al.]. Risk of Hepatocellular Carcinoma Remains High in Patients with HBV-Related Decompensated Cirrhosis and Long-Term Antiviral Therapy. Canadian Journal of Gastroenterology and Hepatology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1139063
American Medical Association (AMA)
Zhu, Dong-Mei& Xie, Jing& Ye, Chun-Yan& Qian, Mei-Yun& Xue, Yuan. Risk of Hepatocellular Carcinoma Remains High in Patients with HBV-Related Decompensated Cirrhosis and Long-Term Antiviral Therapy. Canadian Journal of Gastroenterology and Hepatology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1139063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139063