Assessment of Longitudinal Reproducibility of Mice LV Function Parameters at 11.7 T Derived from Self-Gated CINE MRI
Joint Authors
Rottbauer, Wolfgang
Rasche, Volker
Ma, Genshan
Zuo, Zhi
Subgang, Anne
Abaei, Alireza
Stiller, Detlef
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The objective of this work was the assessment of the reproducibility of self-gated cardiac MRI in mice at ultra-high-field strength.
A group of adult mice (n=5) was followed over 360 days with a standardized MR protocol including reproducible animal position and standardized planning of the scan planes.
From the resulting CINE MRI data, global left ventricular (LV) function parameters including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and left ventricular mass (LVM) were quantified.
The reproducibility of the self-gated technique as well as the intragroup variability and longitudinal changes of the investigated parameters was assessed.
Self-gated cardiac MRI proved excellent reproducibility of the global LV function parameters, which was in the order of the intragroup variability.
Longitudinal assessment did not reveal any significant variations for EDV, ESV, SV, and EF but an expected increase of the LVM with increasing age.
In summary, self-gated MRI in combination with a standardized protocol for animal positioning and scan plane planning ensures reproducible assessment of global LV function parameters.
American Psychological Association (APA)
Zuo, Zhi& Subgang, Anne& Abaei, Alireza& Rottbauer, Wolfgang& Stiller, Detlef& Ma, Genshan…[et al.]. 2017. Assessment of Longitudinal Reproducibility of Mice LV Function Parameters at 11.7 T Derived from Self-Gated CINE MRI. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139065
Modern Language Association (MLA)
Zuo, Zhi…[et al.]. Assessment of Longitudinal Reproducibility of Mice LV Function Parameters at 11.7 T Derived from Self-Gated CINE MRI. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139065
American Medical Association (AMA)
Zuo, Zhi& Subgang, Anne& Abaei, Alireza& Rottbauer, Wolfgang& Stiller, Detlef& Ma, Genshan…[et al.]. Assessment of Longitudinal Reproducibility of Mice LV Function Parameters at 11.7 T Derived from Self-Gated CINE MRI. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139065