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Declining Physical Performance Associates with Serum FasL, miR-21, and miR-146a in Aging Sprinters
Joint Authors
Kangas, Reeta
Alen, Markku
Suominen, Harri
Kovanen, Vuokko
Laakkonen, Eija K.
Korhonen, Marko T.
Törmäkangas, Timo
Heinonen, Ari
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aging is associated with systemic inflammation and cellular apoptosis accelerating physiological dysfunctions.
Whether physically active way of life affects these associations is unclear.
This study measured the levels of serum inflammatory and apoptotic molecules, their change over 10 years, and their associations with physical performance in sprint-trained male athletes.
HsCRP, cell counts, HGB, FasL, miR-21, and miR-146a were measured cross-sectionally (n=67, 18–90 yrs) and serum FasL, miR-21, and miR-146a and their aging-related associations with physical performance were assessed over a 10-year follow-up (n=49, 50–90 yrs).
The cross-sectional study showed positive age correlations for neutrophils and negative for lymphocytes, red blood cells, HGB, FasL, and miR-146a.
During the 10-year follow-up, FasL decreased (P=0.017) and miR-21 (P<0.001) and miR-146a (P=0.005) levels increased.
When combining the molecule levels, aging, and physical performance, FasL associated with countermovement jump and bench press (P<0.001), miR-21 and miR-146a with knee flexion (P=0.023; P<0.001), and bench press (P=0.004; P<0.001) and miR-146a with sprint performance (P<0.001).
The studied serum molecules changed in an age-dependent manner and were associated with declining physical performance.
They have potential as biomarkers of aging-related processes influencing the development of physiological dysfunctions.
Further research is needed focusing on the origins and targets of circulating microRNAs to clarify their function in various tissues with aging.
American Psychological Association (APA)
Kangas, Reeta& Törmäkangas, Timo& Heinonen, Ari& Alen, Markku& Suominen, Harri& Kovanen, Vuokko…[et al.]. 2017. Declining Physical Performance Associates with Serum FasL, miR-21, and miR-146a in Aging Sprinters. BioMed Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1139093
Modern Language Association (MLA)
Kangas, Reeta…[et al.]. Declining Physical Performance Associates with Serum FasL, miR-21, and miR-146a in Aging Sprinters. BioMed Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1139093
American Medical Association (AMA)
Kangas, Reeta& Törmäkangas, Timo& Heinonen, Ari& Alen, Markku& Suominen, Harri& Kovanen, Vuokko…[et al.]. Declining Physical Performance Associates with Serum FasL, miR-21, and miR-146a in Aging Sprinters. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1139093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139093