![](/images/graphics-bg.png)
Joint Detection of Serum IgMIgG Antibody Is an Important Key to Clinical Diagnosis of SARS-CoV-2 Infection
Joint Authors
Hu, Fang
Shang, Xiaoling
Chen, Meizhou
Zhang, Changliang
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
This study was aimed to investigate the application of SARS-CoV-2 IgM and IgG antibodies in diagnosis of COVID-19 infection.
Method.
This study enrolled a total of 178 patients at Huangshi Central Hospital from January to February 2020.
Among them, 68 patients were SARS-CoV-2 infected, confirmed with nucleic acid test (NAT) and CT imaging.
Nine patients were in the suspected group (NAT negative) with fever and other respiratory symptoms.
101 patients were in the control group with other diseases and negative to SARS-CoV-2 infection.
After serum samples were collected, SARS-CoV-2 IgG and IgM antibodies were tested by chemiluminescence immunoassay (CLIA) for all patients.
Results.
The specificity of serum IgM and IgG antibodies to SARS-CoV-2 was 99.01% (100/101) and 96.04% (97/101), respectively, and the sensitivity was 88.24% (60/68) and 97.06% (66/68), respectively.
The combined detection rate of SARS-CoV-2 IgM and IgG antibodies was 98.53% (67/68).
Conclusion.
Combined detection of serum SARS-CoV-2 IgM and IgG antibodies had better sensitivity compared with single IgM or IgG antibody testing, which can be used as an important diagnostic tool for SARS-CoV-2 infection and a screening tool of potential SARS-CoV-2 carriers in clinics, hospitals, and accredited scientific laboratories.
American Psychological Association (APA)
Hu, Fang& Shang, Xiaoling& Chen, Meizhou& Zhang, Changliang. 2020. Joint Detection of Serum IgMIgG Antibody Is an Important Key to Clinical Diagnosis of SARS-CoV-2 Infection. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1139097
Modern Language Association (MLA)
Hu, Fang…[et al.]. Joint Detection of Serum IgMIgG Antibody Is an Important Key to Clinical Diagnosis of SARS-CoV-2 Infection. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1139097
American Medical Association (AMA)
Hu, Fang& Shang, Xiaoling& Chen, Meizhou& Zhang, Changliang. Joint Detection of Serum IgMIgG Antibody Is an Important Key to Clinical Diagnosis of SARS-CoV-2 Infection. Canadian Journal of Infectious Diseases and Medical Microbiology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1139097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139097