Breast Carcinoma: From Initial Tumor Cell Detachment to Settlement at Secondary Sites
Joint Authors
Melzer, Catharina
von der Ohe, Juliane
Hass, Ralf
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Metastasis represents a multistep cascade of cancer cell alterations accompanied by structural and functional changes within the tumor microenvironment which may involve the induction of a retrodifferentiation program.
Major steps in metastatic developments include (A) cell detachment from the primary tumor site involving epithelial-mesenchymal transition (EMT), (B) migration and invasion into surrounding tissue, (C) transendothelial intravasation into the vasculature of blood and/or lymphatic vessels as circulating tumor cells (CTCs), (D) dissemination to distant organs, and (E) extravasation of CTCs to secondary sites as disseminated tumor cells (DTCs).
This article highlights some aspects of the metastatic cascade with a focus on breast cancer cells.
Metastatic steps critically depend on the capability of cancer cells to adapt to distant tissues and the corresponding new microenvironment.
As a consequence, increasing plasticity and developmental changes paralleled by acquisition of new cancer cell functionalities challenge a successful therapeutic approach.
American Psychological Association (APA)
Melzer, Catharina& von der Ohe, Juliane& Hass, Ralf. 2017. Breast Carcinoma: From Initial Tumor Cell Detachment to Settlement at Secondary Sites. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139132
Modern Language Association (MLA)
Melzer, Catharina…[et al.]. Breast Carcinoma: From Initial Tumor Cell Detachment to Settlement at Secondary Sites. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139132
American Medical Association (AMA)
Melzer, Catharina& von der Ohe, Juliane& Hass, Ralf. Breast Carcinoma: From Initial Tumor Cell Detachment to Settlement at Secondary Sites. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139132