Risk Factors of Multidrug-Resistant Bacteria in Lower Respiratory Tract Infections: A Systematic Review and Meta-Analysis
Joint Authors
Chen, Gang
Xu, Kailiang
Sun, Fangyuan
Sun, Yuxia
Kong, Ziyuan
Fang, Bangjiang
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Multidrug-resistant (MDR) bacteria are the main cause of lower respiratory tract infections (LRTIs) with high mortality.
The purpose of this study is to identify the risk factors associated with MDR by performing a systematic review and meta-analysis.
Methods.
PubMed, EMBASE (via Ovid), and Cochrane Library were systematically searched for studies on the risk factors for MDR bacteria in LRTIs as of November 30, 2019.
Literature screening, data abstraction, and quality assessment of the eligible studies were performed independently by two researchers.
Results.
A total of 3,607 articles were retrieved, of which 21 articles representing 20 cohort studies published in English were included after title/abstract and full-text screening.
Among the 21 articles involving 7,650 patients and 1,360 MDR organisms, ten reported the risk factors for MDR Gram-positive bacteria (GPB) and Gram-negative bacteria (GNB), ten for MDR GNB, and one for MDR GPB.
The meta-analysis results suggested that prior antibiotic treatment, inappropriate antibiotic therapy, chronic lung disease, chronic liver disease and cerebral disease, prior MDR and PA infection/colonization, recent hospitalization, longer hospitalization stay, endotracheal tracheostomy and mechanical ventilation, tube feeding, nursing home residence, and higher disease severity score were independent risk factors for MDR bacteria.
Conclusions.
This review identified fourteen clinical factors that might increase the risk of MDR bacteria in patients with LRTIs.
Clinicians could take into account these factors when selecting antibiotics for patients and determine whether coverage for MDR bacteria is required.
More well-designed studies are needed to confirm the various risk factors for MDR bacteria in the future.
American Psychological Association (APA)
Chen, Gang& Xu, Kailiang& Sun, Fangyuan& Sun, Yuxia& Kong, Ziyuan& Fang, Bangjiang. 2020. Risk Factors of Multidrug-Resistant Bacteria in Lower Respiratory Tract Infections: A Systematic Review and Meta-Analysis. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1139172
Modern Language Association (MLA)
Chen, Gang…[et al.]. Risk Factors of Multidrug-Resistant Bacteria in Lower Respiratory Tract Infections: A Systematic Review and Meta-Analysis. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1139172
American Medical Association (AMA)
Chen, Gang& Xu, Kailiang& Sun, Fangyuan& Sun, Yuxia& Kong, Ziyuan& Fang, Bangjiang. Risk Factors of Multidrug-Resistant Bacteria in Lower Respiratory Tract Infections: A Systematic Review and Meta-Analysis. Canadian Journal of Infectious Diseases and Medical Microbiology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1139172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139172