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An ECM-Mimicking, Mesenchymal Stem Cell-Embedded Hybrid Scaffold for Bone Regeneration
Joint Authors
Haj, Jozafina
Haj Khalil, Tharwat
Falah, Mizied
Zussman, Eyal
Srouji, Samer
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
While biologically feasible, bone repair is often inadequate, particularly in cases of large defects.
The search for effective bone regeneration strategies has led to the emergence of bone tissue engineering (TE) techniques.
When integrating electrospinning techniques, scaffolds featuring randomly oriented or aligned fibers, characteristic of the extracellular matrix (ECM), can be fabricated.
In parallel, mesenchymal stem cells (MSCs), which are capable of both self-renewing and differentiating into numerous tissue types, have been suggested to be a suitable option for cell-based tissue engineering therapies.
This work aimed to create a novel biocompatible hybrid scaffold composed of electrospun polymeric nanofibers combined with osteoconductive ceramics, loaded with human MSCs, to yield a tissue-like construct to promote in vivo bone formation.
Characterization of the cell-embedded scaffolds demonstrated their resemblance to bone tissue extracellular matrix, on both micro- and nanoscales and MSC viability and integration within the electrospun nanofibers.
Subcutaneous implantation of the cell-embedded scaffolds in the dorsal side of mice led to new bone, muscle, adipose, and connective tissue formation within 8 weeks.
This hybrid scaffold may represent a step forward in the pursuit of advanced bone tissue engineering scaffolds.
American Psychological Association (APA)
Haj, Jozafina& Haj Khalil, Tharwat& Falah, Mizied& Zussman, Eyal& Srouji, Samer. 2017. An ECM-Mimicking, Mesenchymal Stem Cell-Embedded Hybrid Scaffold for Bone Regeneration. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1139173
Modern Language Association (MLA)
Haj, Jozafina…[et al.]. An ECM-Mimicking, Mesenchymal Stem Cell-Embedded Hybrid Scaffold for Bone Regeneration. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1139173
American Medical Association (AMA)
Haj, Jozafina& Haj Khalil, Tharwat& Falah, Mizied& Zussman, Eyal& Srouji, Samer. An ECM-Mimicking, Mesenchymal Stem Cell-Embedded Hybrid Scaffold for Bone Regeneration. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1139173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139173