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Coinfection of High-Risk Human Papillomavirus and Lower Genital Tract Pathogens in the Development of High-Grade Cervical Lesions
Joint Authors
Zhong, Hui
Tong, Yao
Lin, Haifeng
Mao, Xiaodan
Dong, Binhua
Wu, Zhihui
Chen, Huiyu
Sun, Pengming
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
This study investigated the infection status and relationship between other common lower genital tract infectious pathogens and high-risk human papillomavirus (HR-HPV) in the high-grade cervical lesions.
Methods.
Overall, 882 patients were enrolled in this retrospective study, of which 339 patients (≥HSIL group) were confirmed with high-grade squamous intraepithelial lesions (HSIL) or cervical squamous cell carcinoma (SCC), while 543 patients (≤LSIL group) were diagnosed with low-grade squamous intraepithelial lesions (LSIL) or normal cervical pathology diagnosis.
Cervical swab specimens were tested for HPV, pathogenic bacteria (PB), U.
urealyticum (UU), M.
hominis (MH), and C.
trachomatis (CT) in both groups.
Results.
The infection rates of HR-HPV, PB, UU (at high density), and CT were higher in the ≥HSIL group than in the ≤LSIL group (P<0.001); however, higher infection rates with MH were not observed (P>0.05).
PB, UU, and CT were associated with HR-HPV infection (P<0.001).
The PB and UU infection rates in the ≥HSIL group were significantly different from those in the ≤LSIL group, regardless of whether there was an HR-HPV infection at the same time (P<0.05).
However, this was not the case for the CT (P>0.05).
Furthermore, 259 pathogenic bacterial strains were detected in 882 cases.
The difference in the distribution of pathogenic bacterial flora in the different grades of cervical lesions had no statistical significance, which was prioritized over Escherichia coli (P>0.05).
Conclusion.
PB, UU, and CT infection is associated with susceptibility to HR-HPV, HR-HPV coinfection with these pathogens might increase the risk of high-grade cervical lesions, and PB and UU might be independent risk factors for cervical lesions.
American Psychological Association (APA)
Zhong, Hui& Tong, Yao& Lin, Haifeng& Mao, Xiaodan& Dong, Binhua& Wu, Zhihui…[et al.]. 2020. Coinfection of High-Risk Human Papillomavirus and Lower Genital Tract Pathogens in the Development of High-Grade Cervical Lesions. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1139176
Modern Language Association (MLA)
Zhong, Hui…[et al.]. Coinfection of High-Risk Human Papillomavirus and Lower Genital Tract Pathogens in the Development of High-Grade Cervical Lesions. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1139176
American Medical Association (AMA)
Zhong, Hui& Tong, Yao& Lin, Haifeng& Mao, Xiaodan& Dong, Binhua& Wu, Zhihui…[et al.]. Coinfection of High-Risk Human Papillomavirus and Lower Genital Tract Pathogens in the Development of High-Grade Cervical Lesions. Canadian Journal of Infectious Diseases and Medical Microbiology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1139176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139176