Low Frequency Electrical Stimulation Either Prior to Or after Rapid Kindling Stimulation Inhibits the Kindling-Induced Epileptogenesis
Joint Authors
Yadollahpour, Ali
Jalilifar, Mostafa
Moazedi, Ahmad Ali
Ghotbeddin, Zohreh
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Studies are ongoing to find appropriate low frequency stimulation (LFS) protocol for treatment of epilepsy.
The present study aimed at assessing the antiepileptogenesis effects of LFS with the same protocol applied either just before or immediately after kindling stimulations.
Method.
This experimental animal study was conducted on adult Wistar rats (200 ± 20 g) randomly divided into kindle (n=7), LFS + Kindle (n=6), and Kindle + LFS groups (n=6).
All animals underwent rapid kindling procedure and four packages of LFS (1 Hz) with 5 min interval were applied either immediately before (LFS-K) or after kindling stimulation (K-LFS).
The after discharge duration (ADD), daily stages of kindling, and kindling seizure stage and number of stimulations required to reach each stage were compared between the three groups using two-way analysis of variance (ANOVA) followed by Tukey post hoc and one-way ANOVA, and Kruskal-Wallis test, respectively.
Results.
LFS in both protocols significantly decreased the ADD (p<0.05) and daily seizure stages (p<0.05) and increased the number of stimulations required to achieve stage 3 and stages 4 and 5 of kindling compared with the kindle group (stage 2: p>0.05, stages 3 to 5: p<0.05).
Conclusion.
Although LFS-K showed more inhibiting effect than K-LFS, the difference was not statistically significant.
American Psychological Association (APA)
Jalilifar, Mostafa& Yadollahpour, Ali& Moazedi, Ahmad Ali& Ghotbeddin, Zohreh. 2017. Low Frequency Electrical Stimulation Either Prior to Or after Rapid Kindling Stimulation Inhibits the Kindling-Induced Epileptogenesis. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139199
Modern Language Association (MLA)
Jalilifar, Mostafa…[et al.]. Low Frequency Electrical Stimulation Either Prior to Or after Rapid Kindling Stimulation Inhibits the Kindling-Induced Epileptogenesis. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1139199
American Medical Association (AMA)
Jalilifar, Mostafa& Yadollahpour, Ali& Moazedi, Ahmad Ali& Ghotbeddin, Zohreh. Low Frequency Electrical Stimulation Either Prior to Or after Rapid Kindling Stimulation Inhibits the Kindling-Induced Epileptogenesis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139199