Association of the rs562556 PCSK9 Gene Polymorphism with Reduced Mortality in Severe Malaria among Malian Children
Joint Authors
Fedoryak, Olesya
Arama, Charles
Diarra, Issa
Kouriba, Bouréma
Chrétien, Michel
Mbikay, Majambu
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Recent evidence suggests that proprotein convertase subtilisin/kexin type 9 (PCSK9), a downmodulator of cellular uptake of blood cholesterol, also negatively impacts host immune response to microbial infection.
In this study, we investigated whether carrying the loss-of-function (LOF) rs562556 (c.1420 A > G; p.I474 V) PCSK9 single nucleotide polymorphism (SNP) affected the outcome of severe malaria in children.
Archival DNA of a cohort of 207 Malian children suffering from severe malaria was genotyped for the rs562556 SNP.
Sixty-four children were either heterozygous or homozygous for the minor G allele (carriers); 143 children were homozygous for the common A allele (noncarriers).
Among carriers, there was one mortality case (1.6%), compared to 15 cases (10.5%) among noncarriers (p=0.0251), suggesting that the G allele is associated with better survival in severe malaria.
Intriguingly, this allele did not negatively segregate with any of the clinical symptoms linked to mortality in this cohort.
Studies are needed to determine whether PCSK9 inactivation promotes a protective immune response to malaria infection.
American Psychological Association (APA)
Fedoryak, Olesya& Arama, Charles& Diarra, Issa& Kouriba, Bouréma& Chrétien, Michel& Mbikay, Majambu. 2020. Association of the rs562556 PCSK9 Gene Polymorphism with Reduced Mortality in Severe Malaria among Malian Children. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1139211
Modern Language Association (MLA)
Fedoryak, Olesya…[et al.]. Association of the rs562556 PCSK9 Gene Polymorphism with Reduced Mortality in Severe Malaria among Malian Children. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1139211
American Medical Association (AMA)
Fedoryak, Olesya& Arama, Charles& Diarra, Issa& Kouriba, Bouréma& Chrétien, Michel& Mbikay, Majambu. Association of the rs562556 PCSK9 Gene Polymorphism with Reduced Mortality in Severe Malaria among Malian Children. Canadian Journal of Infectious Diseases and Medical Microbiology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1139211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139211