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Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma
Joint Authors
Amălinei, Cornelia
Lozneanu, Ludmila
Giuşcă, Simona Eliza
Ciobanu Apostol, Delia
Andriescu, Elena Corina
Scripcariu, Alex
Balan, Raluca
Avadanei, Elena Roxana
Căruntu, Irina-Draga
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors.
Aim.
Our study aimed to analyze PN expression in different histological variants of PTC and to correlate its expression with the clinicopathological prognostic factors.
Material and Methods.
PN expression has been immunohistochemically assessed in 50 cases of PTC (conventional, follicular, oncocytic, macrofollicular, and tall cell variants), in tumor epithelial cells and intratumoral stroma.
The association between PN expression and clinicopathological characteristics has been evaluated.
Results.
Our results show that PTC presented different patterns of PN immunoreaction, stromal PN being significantly associated with advanced tumor stage and extrathyroidal extension.
No correlations were found between PN overexpression in tumor epithelial cells and clinicopathological features, except for specific histological variants, the highest risk of poor outcome being registered for the conventional subtype in comparison to the oncocytic type.
Conclusions.
Our study demonstrates differences in PN expression in histological subtypes of PTC.
Our results plead in favor of a dominant protumorigenic role of stromal PN, while the action of epithelial PN is less noticeable.
American Psychological Association (APA)
Giuşcă, Simona Eliza& Amălinei, Cornelia& Lozneanu, Ludmila& Ciobanu Apostol, Delia& Andriescu, Elena Corina& Scripcariu, Alex…[et al.]. 2017. Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139227
Modern Language Association (MLA)
Giuşcă, Simona Eliza…[et al.]. Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139227
American Medical Association (AMA)
Giuşcă, Simona Eliza& Amălinei, Cornelia& Lozneanu, Ludmila& Ciobanu Apostol, Delia& Andriescu, Elena Corina& Scripcariu, Alex…[et al.]. Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139227