Preoperatively Grading Rectal Cancer with the Combination of Intravoxel Incoherent Motions Imaging and Diffusion Kurtosis Imaging
Joint Authors
Zhang, Yunfei
Geng, Zhijun
Yin, Shaohan
Lian, Shanshan
He, Haoqiang
Li, Hui
Xie, Chuanmiao
Dai, Yongming
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
To combine Intravoxel Incoherent Motions (IVIM) imaging and diffusion kurtosis imaging (DKI) which can aid in the quantification of different biological inspirations including cellularity, vascularity, and microstructural heterogeneity to preoperatively grade rectal cancer.
Methods.
A total of 58 rectal patients were included into this prospective study.
MRI was performed with a 3T scanner.
Different combinations of IVIM-derived and DKI-derived parameters were performed to grade rectal cancer.
Pearson correlation coefficients were applied to evaluate the correlations.
Binary logistic regression models were established via integrating different DWI parameters for screening the most sensitive parameter.
Receiver operating characteristic analysis was performed for evaluating the diagnostic performance.
Results.
For individual DWI-derived parameters, all parameters except the pseudodiffusion coefficient displayed the capability of grading rectal cancer (p<0.05).
The better discrimination between high- and low-grade rectal cancer was achieved with the combination of different DWI-derived parameters.
Similarly, ROC analysis suggested the combination of D (true diffusion coefficient), f (perfusion fraction), and Kapp (apparent kurtosis coefficient) yielded the best diagnostic performance (AUC = 0.953, p<0.001).
According to the result of binary logistic analysis, cellularity-related D was the most sensitive predictor (odds ratio: 9.350 ± 2.239) for grading rectal cancer.
Conclusion.
The combination of IVIM and DKI holds great potential in accurately grading rectal cancer as IVIM and DKI can provide the quantification of different biological inspirations including cellularity, vascularity, and microstructural heterogeneity.
American Psychological Association (APA)
Geng, Zhijun& Zhang, Yunfei& Yin, Shaohan& Lian, Shanshan& He, Haoqiang& Li, Hui…[et al.]. 2020. Preoperatively Grading Rectal Cancer with the Combination of Intravoxel Incoherent Motions Imaging and Diffusion Kurtosis Imaging. Contrast Media & Molecular Imaging،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1139231
Modern Language Association (MLA)
Geng, Zhijun…[et al.]. Preoperatively Grading Rectal Cancer with the Combination of Intravoxel Incoherent Motions Imaging and Diffusion Kurtosis Imaging. Contrast Media & Molecular Imaging No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1139231
American Medical Association (AMA)
Geng, Zhijun& Zhang, Yunfei& Yin, Shaohan& Lian, Shanshan& He, Haoqiang& Li, Hui…[et al.]. Preoperatively Grading Rectal Cancer with the Combination of Intravoxel Incoherent Motions Imaging and Diffusion Kurtosis Imaging. Contrast Media & Molecular Imaging. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1139231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139231