The Mechanism of Contrast-Induced Acute Kidney Injury and Its Association with Diabetes Mellitus
Joint Authors
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Contrast-induced acute kidney injury (CI-AKI) is the third most common hospital-acquired AKI after AKI induced by renal perfusion insufficiency and nephrotoxic drugs, taking great adverse effects on the prognosis and increasing hospital stay and medical cost.
Diabetes nephropathy (DN) is a common chronic complication of DM (diabetes mellitus), and DN is an independent risk factor for chronic kidney disease (CKD) and CI-AKI.
The incidence of CI-AKI significantly increases in patients with renal injury, especially in DM-related nephropathy.
The etiology of CI-AKI is not fully clear, and research studies on how DM becomes a facilitated factor of CI-AKI are limited.
This review describes the mechanism from three aspects.
① Pathophysiological changes of CI-AKI in kidney under high-glucose status (HGS).
HGS can enhance the oxidative stress and increase ROS which next causes stronger vessel constriction and insufficient oxygen supply in kidney via vasoactive substances.
HGS also aggravates some ion pump load and the latter increases oxygen consumption.
CI-AKI and HGS are mutually causal, making the kidney function continue to decline.
② Immunological changes of DM promoting CI-AKI.
Some innate immune cells and pattern recognition receptors (PRRs) in DM and/or DN may respond to some damage-associated molecular patterns (DAMPs) formed by CI-AKI.
These effects overlap with some pathophysiological changes in hyperglycemia.
③ Signaling pathways related to both CI-AKI and DM.
These pathways involved in CI-AKI are closely associated with apoptosis, inflammation, and ROS production, and some studies suggest that these pathways may be potential targets for alleviating CI-AKI.
In conclusion, the pathogenesis of CI-AKI and the mechanism of DM as a predisposing factor for CI-AKI, especially signaling pathways, need further investigation to provide new clinical approaches to prevent and treat CI-AKI.
American Psychological Association (APA)
Li, Yanfei& Ren, Ke. 2020. The Mechanism of Contrast-Induced Acute Kidney Injury and Its Association with Diabetes Mellitus. Contrast Media & Molecular Imaging،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1139241
Modern Language Association (MLA)
Li, Yanfei& Ren, Ke. The Mechanism of Contrast-Induced Acute Kidney Injury and Its Association with Diabetes Mellitus. Contrast Media & Molecular Imaging No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1139241
American Medical Association (AMA)
Li, Yanfei& Ren, Ke. The Mechanism of Contrast-Induced Acute Kidney Injury and Its Association with Diabetes Mellitus. Contrast Media & Molecular Imaging. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1139241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139241