Autologous Bone Marrow-Derived Stem Cells for Treating Diabetic Neuropathy in Metabolic Syndrome
Joint Authors
Zhu, Kai
Liu, Wei
Yu, Fengchun
Zhou, Zhenghong
Li, Yi-Chen
Fan, Dongsheng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Diabetic neuropathy is one of the most common and serious complications of diabetes mellitus and metabolic syndrome.
The current therapy strategies, including glucose control and pain management, are not effective for most patients.
Growing evidence suggests that infiltration of inflammation factors and deficiency of local neurotrophic and angiogenic factors contribute significantly to the pathologies of diabetic neuropathy.
Experimental and clinical studies have shown that bone marrow-derived stem cells (BMCs) therapy represents a novel and promising strategy for tissue repair through paracrine secretion of multiple cytokines, which has a potential to inhibit inflammation and promote angiogenesis and neurotrophy in diabetic neuropathy.
In this review, we discuss the clinical practice in diabetic neuropathy and the therapeutic effect of BMC.
We subsequently illustrate the functional impairment of autologous BMCs due to the interrupted bone marrow niche in diabetic neuropathy.
We anticipate that the functional restoration of BMCs could improve their therapeutic effect and enable their wide applications in diabetic neuropathy.
American Psychological Association (APA)
Liu, Wei& Yu, Fengchun& Zhou, Zhenghong& Li, Yi-Chen& Fan, Dongsheng& Zhu, Kai. 2017. Autologous Bone Marrow-Derived Stem Cells for Treating Diabetic Neuropathy in Metabolic Syndrome. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139288
Modern Language Association (MLA)
Liu, Wei…[et al.]. Autologous Bone Marrow-Derived Stem Cells for Treating Diabetic Neuropathy in Metabolic Syndrome. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1139288
American Medical Association (AMA)
Liu, Wei& Yu, Fengchun& Zhou, Zhenghong& Li, Yi-Chen& Fan, Dongsheng& Zhu, Kai. Autologous Bone Marrow-Derived Stem Cells for Treating Diabetic Neuropathy in Metabolic Syndrome. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139288