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In Vitro Biological Screening of Hartmannia rosea Extracts
Joint Authors
Khan, Abida Kalsoom
Haq, Ihsan-ul
Rashid, Rehana
Mir, Sadullah
Mehmood, Sadaf
Lu, Yi
Murtaza, Ghulam
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study is focused on the assessment of the medicinal therapeutic potential extracts of H.
rosea to investigate their pharmacological implications based upon science proofs.
The antioxidant activity of fraction of H.
rosea, namely, n-hexane (HR-1), ethyl acetate (HR-2), chloroform (HR-3), and n-butanol (HR-4), was performed by using the DPPH radical scavenging method.
The cytotoxicity and enzyme inhibition assessment were also performed.
All the extracts showed significant antioxidant, antibacterial, and protein kinase inhibition but none of the extracts exhibited α-amylase inhibition activity.
The chloroform extract HR-3 may block a kinase receptor from binding to ATP; the lead molecule will be isolated, which may stop cancerous cell growth and demotion of cell division.
It is predicted that ethyl acetate, chloroform, and n-butanol extracts of H.
rosea contain polyphenolics, flavonoids, and alkaloids that are biologically effective candidates exhibiting significant cytotoxicity, antioxidant, and antimicrobial activities.
They may control oxidative damage in the body tissues and act as potential antidiabetic and anticancer agents.
These studies will also be helpful for future drug designing and drug development research.
American Psychological Association (APA)
Rashid, Rehana& Khan, Abida Kalsoom& Haq, Ihsan-ul& Mir, Sadullah& Mehmood, Sadaf& Lu, Yi…[et al.]. 2017. In Vitro Biological Screening of Hartmannia rosea Extracts. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139293
Modern Language Association (MLA)
Rashid, Rehana…[et al.]. In Vitro Biological Screening of Hartmannia rosea Extracts. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1139293
American Medical Association (AMA)
Rashid, Rehana& Khan, Abida Kalsoom& Haq, Ihsan-ul& Mir, Sadullah& Mehmood, Sadaf& Lu, Yi…[et al.]. In Vitro Biological Screening of Hartmannia rosea Extracts. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1139293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139293