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Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis
Joint Authors
Li, Shugang
Jing, Mingxia
Liu, Mingzhu
Yan, Xiaolong
Zhang, Mei
Li, Xiaoju
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To provide a scientific basis for the prevention and treatment of cervical intraepithelial neoplasia grade 1 (CIN1).
This study evaluated the impact of human papillomavirus (HPV) infection on the natural history of CIN1.
Methods.
Electronic databases of Cochrane Library, EMBASE, PubMed, CNKI, CBM, and Wanfang were searched in April 2016.
The eligibility criteria were documented by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
We used the Newcastle-Ottawa scale (NOS) to assess study quality.
Results.
Thirty-eight studies out of 3,246 identified papers were eligible for inclusion.
The risk of CIN1 progression (relative risk [RR]: 3.04; 95% confidence interval [CI]: 2.41–3.83; P<0.00001) and persistence (RR: 1.48; 95% CI: 1.17–1.87; P=0.001) was higher in the HPV-positive group than HPV-negative group.
Specifically, the risk of CIN1 progression (RR: 13.91; 95% CI: 3.46–55.90; P=0.000) was higher among persistent high-risk HPV-positive patients and the ratio of CIN1 regression (RR: 0.65; 95% CI: 0.59–0.71; P<0.00001) was lower in the HPV-positive group than HPV-negative group.
Conclusion.
HPV infection resulted in an increased risk of CIN1 progression and decreased disease reversibility.
Persistent high-risk HPV infection resulted in a further increased risk of CIN1 progression.
American Psychological Association (APA)
Liu, Mingzhu& Yan, Xiaolong& Zhang, Mei& Li, Xiaoju& Li, Shugang& Jing, Mingxia. 2017. Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139295
Modern Language Association (MLA)
Liu, Mingzhu…[et al.]. Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1139295
American Medical Association (AMA)
Liu, Mingzhu& Yan, Xiaolong& Zhang, Mei& Li, Xiaoju& Li, Shugang& Jing, Mingxia. Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1139295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139295