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Nutraceutical, Anti-Inflammatory, and Immune Modulatory Effects of β-Glucan Isolated from Yeast
Joint Authors
Bacha, Umar
Nasir, Muhammad
Iqbal, Sanaullah
Anjum, Aftab Ahmad
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
β -Glucan is a dietary fibre, found in many natural sources, and controls chronic metabolic diseases effectively.
However, β-glucan from the yeast has rarely been investigated.
Objectively, conditions were optimized to isolate β-glucan from the yeast (max.
66% yield); those optimized conditions included 1.0 M NaOH, pH 7.0, and 90°C.
The purity and identity of the isolated β-glucan were characterized through FT-IR, SEM, DSC, and physicofunctional properties.
The obtained results from DSC revealed highly stable β-glucan (m.p., 125°C) with antioxidant activity (TAC value 0.240 ± 0.0021 µg/mg, H2O2 scavenging 38%), which has promising bile acid binding 40.463% and glucose control (in vitro).
In line with these results, we evaluated the in vivo anti-inflammatory potential, that is, myeloperoxidase activity and reduction in MDA and NO; protective effect on proteins and keeping viscosity within normal range exhibited improvement.
Also, the in vivo cholesterol binding and reduction in the skin thickness by β-glucan were highly encouraging.
Finally, our results confirmed that yeast β-glucan is effective against some of the inflammatory and oxidative stress markers studied in this investigation.
In general, the effect of 4% β-glucan was more noticeable versus 2% β-glucan.
Therefore, our results support the utilization of β-glucan as a novel, economically cheap, and functional food ingredient.
American Psychological Association (APA)
Bacha, Umar& Nasir, Muhammad& Iqbal, Sanaullah& Anjum, Aftab Ahmad. 2017. Nutraceutical, Anti-Inflammatory, and Immune Modulatory Effects of β-Glucan Isolated from Yeast. BioMed Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1139296
Modern Language Association (MLA)
Bacha, Umar…[et al.]. Nutraceutical, Anti-Inflammatory, and Immune Modulatory Effects of β-Glucan Isolated from Yeast. BioMed Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1139296
American Medical Association (AMA)
Bacha, Umar& Nasir, Muhammad& Iqbal, Sanaullah& Anjum, Aftab Ahmad. Nutraceutical, Anti-Inflammatory, and Immune Modulatory Effects of β-Glucan Isolated from Yeast. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1139296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139296