MiR-219-5p Inhibits the Growth and Metastasis of Malignant Melanoma by Targeting BCL-2

Abstract EN

Malignant melanoma is a very dangerous tumor which is resistant to conventional therapy.

MicroRNA exerts a vital function in promoting or inhibiting tumor development.

The research has investigated the expression and function of miR-219-5p in melanoma.

As a result, miR-219-5p expression was distinctly reduced in melanoma tissues and cell lines and was negatively correlated with Bcl-2 protein level in melanoma.

Patients with low miR-219-5p level represented obviously a low overall survival in comparison with patients with high miR-219-5p level.

The upregulation of miR-219-5p inhibited melanoma growth and metastasis and strengthened melanoma cells chemosensitivity by targeting Bcl-2.

Therefore, the modulation of miR-219-5p expression may be a novel treatment strategy in melanoma.