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The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients
Joint Authors
Chen, Nai-Ching
Hsu, Chih-Yang
Chen, Chien-Liang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The high prevalence of arterial calcification in end-stage renal disease (ESRD) is far beyond the explanation by common cardiovascular risk factors such as aging, diabetes, hypertension, and dyslipidemia.
The finding relies on the fact that vascular and valvular calcifications are predictors of cardiovascular diseases and mortality in persons with chronic renal failure.
In addition to traditional cardiovascular risk factors such as diabetes mellitus and blood pressure control, other ESRD-related risks such as phosphate retention, excess calcium, and prolonged dialysis time also contribute to the development of vascular calcification.
The strategies are to reverse “calcium paradox” and lower vascular calcification by decreasing procalcific factors including minimization of inflammation (through adequate dialysis and by avoiding malnutrition, intravenous labile iron, and positive calcium and phosphate balance), correction of high and low bone turnover, and restoration of anticalcification factor balance such as correction of vitamin D and K deficiency; parathyroid intervention is reserved for severe hyperparathyroidism.
The role of bone antiresorption therapy such as bisphosphonates and denosumab in vascular calcification in high-bone-turnover disease remains unclear.
The limited data on sodium thiosulfate are promising.
However, if calcification is to be targeted, ensure that bone health is not compromised by the treatments.
American Psychological Association (APA)
Chen, Nai-Ching& Hsu, Chih-Yang& Chen, Chien-Liang. 2017. The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139308
Modern Language Association (MLA)
Chen, Nai-Ching…[et al.]. The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1139308
American Medical Association (AMA)
Chen, Nai-Ching& Hsu, Chih-Yang& Chen, Chien-Liang. The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1139308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139308