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Phagocytosis: A Fundamental Process in Immunity
Joint Authors
Rosales, C.
Uribe-Querol, Eileen
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-12
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
One hundred years have passed since the death of Élie Metchnikoff (1845–1916).
He was the first to observe the uptake of particles by cells and realized the importance of this process for the host response to injury and infection.
He also was a strong advocate of the role of phagocytosis in cellular immunity, and with this he gave us the basis for our modern understanding of inflammation and the innate and acquired immune responses.
Phagocytosis is an elegant but complex process for the ingestion and elimination of pathogens, but it is also important for the elimination of apoptotic cells and hence fundamental for tissue homeostasis.
Phagocytosis can be divided into four main steps: (i) recognition of the target particle, (ii) signaling to activate the internalization machinery, (iii) phagosome formation, and (iv) phagolysosome maturation.
In recent years, the use of new tools of molecular biology and microscopy has provided new insights into the cellular mechanisms of phagocytosis.
In this review, we present a general view of our current knowledge on phagocytosis.
We emphasize novel molecular findings, particularly on phagosome formation and maturation, and discuss aspects that remain incompletely understood.
American Psychological Association (APA)
Rosales, C.& Uribe-Querol, Eileen. 2017. Phagocytosis: A Fundamental Process in Immunity. BioMed Research International،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1139311
Modern Language Association (MLA)
Rosales, C.& Uribe-Querol, Eileen. Phagocytosis: A Fundamental Process in Immunity. BioMed Research International No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1139311
American Medical Association (AMA)
Rosales, C.& Uribe-Querol, Eileen. Phagocytosis: A Fundamental Process in Immunity. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1139311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139311